COVID-19 trials registries data warehouse

http://www.chictr.org.cn/showproj.aspx?proj=51329

Zhaohui Tong

tongzhaohuicy@sina.com

2020-03-20

Recruiting

RCT

Randomized

Parallel

Not reported

single-center

Treatment

1. Male and female aged 18-75 years old, 2. Patients previously diagnosed with COVID-2019: the course of illness is no more than 14 days,If the course of disease was more than 14 days, patients meeting one of the following conditions could also be included: (1) no obvious absorption or progression of chest lesions within 7 days, (2) respiratory symptoms (chest tightness, or cough, or breathing difficulties), Nucleic acid positive within 3 days 3. sign the informed consent, 4. Agree to collect clinical samples, 5. Female or male subjects of childbearing age agree to take effective contraceptive measures within 3 months of the last oral medication to ensure that female or male partners of childbearing age are not pregnant.

1. Cases of severe vomiting or difficulty in ingesting medication, 2. Pregnant and lactating women, 3. Lopinavir/ridonavir, ribavirin, interferon and monoclonal antibody were received 3 days before enrollment, 4. Cases of respiratory failure requiring mechanical ventilation, 5. Cases of shock, 6. Complications of other organ failure require ICU care, 7. Patients were clinically predicted with no hope of survival and only received hospice care, or those who were in a deep coma and did not respond to supportive treatment measures within three hours of admission.

3

Beijing Chao-yang Hospital; Capital Medical University

18

75

China

No restriction on type of patients

0: No restriction on type of patients

150

improvement or recovery of respiratory symptoms;viral nucleic acid shedding;

| Declared number of arm (3.0) differs from found arms (4.0)

Phase 2/Phase 3

[{"arm_notes": "", "treatment_id": 1456, "treatment_name": "Chloroquine+favipiravir", "treatment_type": "Antimalarials+antivirals", "pharmacological_treatment": "Pharmacological treatment"}, {"arm_notes": "", "treatment_id": 504, "treatment_name": "Favipiravir", "treatment_type": "Antivirals", "pharmacological_treatment": "Pharmacological treatment"}, {"arm_notes": "", "treatment_id": 2187, "treatment_name": "Placebo", "treatment_type": "Placebo", "pharmacological_treatment": "Placebo"}]