COVID-19 trials registries data warehouse

http://www.chictr.org.cn/showproj.aspx?proj=51141

Bin Zhang/Yinong Ye

FSYYN001@126.com

2020-03-17

Recruiting

RCT

Randomized

Parallel

Open label

multi-center

Treatment

(1) Aged 18 to 65 years old, (2) Patients with mild or normal type who have been diagnosed with new type of coronavirus infection [in accordance with the diagnostic criteria of the Notice on Printing and Distributing New Coronavirus Pneumonia Diagnosis and Treatment Plan (Trial Implementation) issued by the National Health and Medical Commission], (3) According to the National Health and Health Commission's antiviral treatment for more than 10 days, the COVID-19 nucleic acid examination of the throat swabs/putum /stool samples was still positive or weakly positive.

(1) Female patients who are pregnant or planning to become pregnant within 7 months, (2) ALT is higher than 10 times the upper limit of normal value, or total bilirubin is highter than 2 times the upper limit of normal value, or the stage of decompensation of cirrhosis, or has had decompensation of cirrhosis, (3) The number of peripheral blood leukocytes and/or platelets is lower than the lower limit of normal value, (4) There are serious important organs such as cardiovascular,lung,kidney,brain lesions and fundus lesions, (5) Combined with autoimmune disease,mental illness,diabetes,and abnormal thyroid function (hyperthyroidism or hypothyroidism), (6) Those diagnosed or suspected of malignant tumors, (7) Those who are using immunosuppressive drugs or after organ transplantation or who are preparing to undergo organ transplantation, (8) Drug addicts or people with HIV infection, (9) Those who are allergic to interferon, (10) There are other situations in which interferon is not suitable for use by the doctor in charge, (11) Men who did not take effective contraception during and after the treatment period.

2

Foshan First People's Hospital

18

65

China

Mild/moderate disease at enrollment

2: Mild/moderate disease at enrollment

30

COVID-19 nucleic acid negative conversion rate;Causal mortality;All-cause mortality;

| Declared number of arm (2.0) differs from found arms (3.0)

Not reported

[{"arm_notes": "", "treatment_id": 2210, "treatment_name": "Interferon alpha 2a+ribavirin", "treatment_type": "Interferons+antivirals", "pharmacological_treatment": "Pharmacological treatment"}, {"arm_notes": "", "treatment_id": 1724, "treatment_name": "Interferon alpha+umifenovir", "treatment_type": "Interferons+antivirals", "pharmacological_treatment": "Pharmacological treatment"}]