COVID-19 trials registries data warehouse

http://www.chictr.org.cn/showproj.aspx?proj=50241

Yun Lin

frank0130@126.com

2020-02-28

Terminated

RCT

Randomized

Sequential assignment

Not reported

single-center

Treatment

(1) Comply with the diagnostic criteria for general type COVID-19 in the Diagnosis and Treatment Program for COVID-19 (trial version 6th), (2) Patients =18 years of age with tracheal intubation, (3) Agree to participate in the trial, and the patient, the legal guardian or the person in charge of the medical institution signed the informed consent through paper signature, electronic signature of mobile phone software, or voice authorization.

1.Serious basic diseases affecting survival, including: uncontrolled malignant tumor with multiple metastases that cannot be removed, hematological diseases, cachexia, active hemorrhage, severe malnutrition, AIDS, etc., 2.Obstructive pneumonia, severe pulmonary interstitial fibrosis, alveolar proteinosis and allergic alveolitis caused by lung tumor, 3.Use in vitro life support (ECMO, ECCO2R), 4.Patients with bronchial asthma, peptic ulcer, and patients allergic to acetylcysteine, 5.Any potential violation of test compliance or any other circumstance affecting safety and effectiveness evaluation that may exist, which the researchers believe is not suitable for patients participating in the study.

2

Union Hospital; Tongji Medical College; Huazhong University of Science & Technology

18

None

China

Severe/critical disease at enrollment

7: Severe/critical disease at enrollment

60

Lung CT after 3 days;Lung CT after 7 days;Oxygenation parameters: SpO2; Partial arterial oxygen pressure (PaO2); PaO2/FiO2;Hospital stay;Novel coronavirus nucleic acid detection;Recurrence rate;

The Study is Cancelled by the investigator | Declared number of arm (2.0) differs from found arms (3.0)

Phase 4

[{"arm_notes": "", "treatment_id": 18, "treatment_name": "Acetylcysteine", "treatment_type": "Respiratory agents", "pharmacological_treatment": "Pharmacological treatment"}, {"arm_notes": "", "treatment_id": 2187, "treatment_name": "Placebo", "treatment_type": "Placebo", "pharmacological_treatment": "Placebo"}]