COVID-19 trials registries data warehouse

https://clinicaltrials.gov/show/NCT05255848

Muhammad Imran, MBBS, FCPS

m.imran@lrh.edu.pk

2022-02-25

Not recruiting

RCT

Randomized

Single group assignment

Open label

single-center

Treatment

inclusion criteria: age 18 year or older. either gender currently admitted to hospital. there is a pcr-positive sample for sars-cov-2 within the past 21 days. the sample can be a nasal or pharyngeal swab, sputum, tracheal aspirate, broncho alveolar lavage, or another sample from the patient who modified ordinal clinical scale 3-5

intubated and on mechanical ventilation, or requiring immediate intubation as per the treating clinician's assessment heparin allergy or heparin-induced thrombocytopenia aptt >120 s, not due to anticoagulant therapy and does not correct with the administration of fresh frozen plasma platelet count <20 × 109 /l pulmonary bleeding or uncontrolled bleeding pregnant or might be pregnant acute brain injury that may result in long-term disability myopathy, spinal cord injury, or nerve injury or disease with a likely prolonged incapacity to breathe independently e.g. guillain-barre syndrome treatment limitations in place (ceiling of care), i.e. not for intubation, not for icu admission death is imminent or inevitable within 24 h clinician objection refusal to consent

2

Lady Reading Hospital, Pakistan

18

100

Pakistan

Moderate/severe disease at enrollment

4: Moderate/severe disease at enrollment

180

Number of patients requiring Intubation

None

Phase 2/Phase 3

[{"arm_notes": "", "treatment_id": 1337, "treatment_name": "Unfractioned heparin", "treatment_type": "Coagulation modifiers", "pharmacological_treatment": "Pharmacological treatment"}, {"arm_notes": "", "treatment_id": 2188, "treatment_name": "Standard of care", "treatment_type": "Standard of care", "pharmacological_treatment": "Standard of care"}]