COVID-19 trials registries data warehouse

https://clinicaltrials.gov/show/NCT04988282

Not reported

Not reported

2021-08-03

Completed

RCT

Randomized

Parallel

Open label

single-center

Long covid

inclusion criteria: post-covid-19 interstitial lung disease (ild) patients who had completed the treatment of acute phase and have recovered, but despite after 90 days from recovery diagnosed as post-covid ild based upon the persistent respiratory symptoms with functional impairment and radiological sequela. at least 90 days required after discharge for hospitalized patients or termination of isolation for outpatients confirmation of the diagnosis of covid-19 via real time polymerase chain reaction assay (rt-pcr) or antigen or antibody test in the acute phase of covid-19. presence of sequelae interstitial changes in follow-up (pre-enrollment) thorax high-resolution computed tomography (hrct)/ct. presence of persistent respiratory symptoms in the post-covid-19 period or hypoxemia at rest and/or desaturation with exercise.

patients who had a normal lung imaging examination (radiography, tomography, etc.) at discharge or enrollment phase pre-existing diffuse parenchymal lung disease before pandemic cystic bronchiectasis presence of contraindications for systemic corticosteroids (uncontrolled diabetes, uncontrolled hypertension, unstable angina pectoris, history of acute coronary syndrome at last month, presence of active infection, active peptic ulcer, presence of uncontrolled psychiatric disease, etc.) decompensated heart failure contraindications for pulmonary function tests and those who cannot cooperate with the test younger than 18 years old pregnant women breastfeeding women those who do not give written consent

2

Turkish Thoracic Society

18

100

Turkey

Patients recovered from covid

N/A

262

% of patients with clinical improvement;% of patients with functional improvement;% of patients with radiological improvement

None

Phase 4

[{"arm_notes": "", "treatment_id": 798, "treatment_name": "Methylprednisolone", "treatment_type": "Corticosteroids", "pharmacological_treatment": "Pharmacological treatment"}, {"arm_notes": "", "treatment_id": 2188, "treatment_name": "Standard of care", "treatment_type": "Standard of care", "pharmacological_treatment": "Standard of care"}]