COVID-19 trials registries data warehouse

https://clinicaltrials.gov/show/NCT04290858

Lei Chong, MD, PhD; Lorenzo Berra, MD

Not reported

2020-03-02

Withdrawn

RCT

Randomized

Parallel

Open label

unclear

Treatment

inclusion criteria: laboratory confirmed covid19 infection defined with a positive rt-pcr from any specimen. hospital admission with at least one of the following: fever ≥ 36.6 °c from axillary site; or ≥ 37.2°c from oral site; or ≥ 37.6°c from tympanic or rectal site. respiratory rate ≥ 24 bpm cough spontaneous breathing with or without hypoxia of any degree. gas exchange and ventilation maybe assisted by any continuous continuous airway pressure (cpap), or any system of non invasive ventilation (niv), with positive end-expiratory pressure (peep) ≤ 10 cmh2o. ≤ 8 days since onset of the symptoms

pregnancy, or positive pregnancy test in a predose examination open tracheostomy therapy with high flow nasal cannula clinical controindication, as deemed by the attending physician

2

Xijing Hospital

18

100

None

Moderate/severe disease at enrollment

4: Moderate/severe disease at enrollment

0

Reduction in the incidence of intubation and mechanical ventilation

None

Phase 2

[{"arm_notes": "", "treatment_id": 890, "treatment_name": "Nitric oxide gas", "treatment_type": "Gas inhalation", "pharmacological_treatment": "Non pharmacological treatment"}, {"arm_notes": "", "treatment_id": 2188, "treatment_name": "Standard of care", "treatment_type": "Standard of care", "pharmacological_treatment": "Standard of care"}]