COVID-19 trials registries data warehouse

https://clinicaltrials.gov/show/NCT04793984

Not reported

Not reported

2021-03-11

Completed

RCT

Randomized

Parallel

Blind label

single-center

Treatment

inclusion criteria: - written informed consent obtained before any trial related procedures are performed - age ≥ 18 years - hospitalized patients with pcr confirmed sars-cov-2 infection and symptom onset ≤ 10 days before randomization - patients with respiratory covid-19 symptoms - randomization ≤ 48h from admission - peripheral capillary oxygen saturation (spo2) ≥ 90% on room air or supplemental oxygen at screening - patient agrees to refrain from taking other carragelose products (e.g. throat spray, lozenges)

- no informed consent - persistent hypoxemia with spo2 < 90% despite supplemental oxygen of > 6lo2/min at screening. - patients with predominantly extrapulmonary covid-19 symptoms (e.g. gastrointestinal, neurological, etc.) - subjects who demonstrate respiratory and/or cardiac instability that is considered by the investigator as a reason for exclusion. additionally, any other clinically significant disease that could interfere with participation in the study, with the intervention being studied, or with the evaluation of symptoms. specific exclusions are asthma, immune deficiency, autoimmune disease, clinically significant cardiovascular, endocrinological, neurological, respiratory, gastrointestinal disease or any disease that is considered by the investigator as a reason for exclusion. - known hypersensitivity or allergy to any component of the test product - the subject is related to any study personnel or has any other close ties or conflicts of interest with the study sponsor. - the subject has received any investigational drug or participated in a clinical trial within 4 weeks of entry to this study - current medication other than oral contraception,that is considered by the investigator as a reason for exclusion. - pregnant/lactating women at the time of recruitment will be excluded from the study - participation in another antiviral clinical trial

2

Marinomed Biotech AG

18

100

Austria

Moderate/severe disease at enrollment

4: Moderate/severe disease at enrollment

14

Clinical status of subjects as expressed on the WHO-8-Category ordinal scale:

None

Not reported

[{"arm_notes": "", "treatment_id": 255, "treatment_name": "Carragelose", "treatment_type": "Others non pharmacological treatment", "pharmacological_treatment": "Non pharmacological treatment"}, {"arm_notes": "", "treatment_id": 2187, "treatment_name": "Placebo", "treatment_type": "Placebo", "pharmacological_treatment": "Placebo"}]