COVID-19 trials registries data warehouse

https://clinicaltrials.gov/show/NCT04780581

Not reported

Not reported

2021-03-03

Terminated

RCT

Randomized

Parallel

Open label

multi-center

Treatment

inclusion criteria: over 18 years of age inpatient diagnosis of sars-cov-2 infection confirmed by reverse transcriptase polymerase chain reaction (rt-pcr) or antigen they present evidence in computerized axial tomography (ct) of pulmonary involvement attributed to the infection by covid. patients in whom ct scans are not performed must have suspected pulmonary involvement by clinical examination with simple compatible or suggestive radiology. requires supplementary oxygen due to basal saturation ≤ 93% (with ambient o2, 21%)

the patient's situation is so serious that the doctor in charge thinks he could die within 24 hours. at the time of randomisation, patients require one of the following 4 ventilatory supports: high-flow oxygen devices. non-invasive mechanical ventilation. invasive mechanical ventilation. extracorporeal membrane oxygenation (ecmo). the patient is or has been treated in the 2 weeks prior to randomisation with glucocorticoids or inflammation modifying drugs, both conventional (thiopurines, cyclophosphamide, cyclosporine, tacrolimus), leflunomide, methotrexate, mycophenolate mofetil/mycophenolic acid, sulfasalazine, hydroxychloroquine or chloroquine) as synthetics or biologics directed against therapeutic targets (abatacept, belimumab, cd-20, il1, il6, il12. 23, il-23, il.17, tnf, integrin α4β7 or janus kinase inhibitors jak). patients who are only on maintenance treatment with doses of steroids less than or equal to 7.5 mg of prednisone or equivalent per day will not be excluded. the patient is pregnant or breastfeeding. the patient has a chronic renal disease is stage 4 or 5 (ccr <30 ml/min). moderate to severe dementia at the investigator's discretion. hypersensitivity to any of the active ingredients or to any of the excipients included in its formulation. untreated systemic infections not caused by covid-19. active stomach or duodenal ulcer. recent vaccination with live vaccines. other infection or disease that explains the lung disorder. inability of the patient to understand the study or to sign the informed consent unless consent is delegated to a legal representative. active participation in another clinical study in the last 15 days.

2

Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León

18

100

Spain

Severe disease at enrollment

6: Severe disease at enrollment

127

Mortality rate in COVID-19 patients after high-dose methylprednisolone bolus administration versus mortality rate intermediate-dose dexamethasone pattern (RECOVERY trial)

None

Phase 4

[{"arm_notes": "", "treatment_id": 798, "treatment_name": "Methylprednisolone", "treatment_type": "Corticosteroids", "pharmacological_treatment": "Pharmacological treatment"}, {"arm_notes": "", "treatment_id": 400, "treatment_name": "Dexamethasone", "treatment_type": "Corticosteroids", "pharmacological_treatment": "Pharmacological treatment"}]