v3.0.7
Please consider this website is continuously evolving and still under development
to harmonize automatic data extraction and integrate manual data annotation.
| Column | Value |
|---|---|
| Trial registration number | NCT04591210 |
|
Full text link
Last imported at : Oct. 26, 2020, 11:31 p.m. Source : ClinicalTrials.gov |
|
|
First author
Last imported at : May 31, 2023, 4 p.m. Source : ClinicalTrials.gov |
|
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Contact
Last imported at : May 31, 2023, 4 p.m. Source : ClinicalTrials.gov |
Not reported |
|
Registration date
Last imported at : Oct. 26, 2020, 11:31 p.m. Source : ClinicalTrials.gov |
2020-10-19 |
|
Recruitment status
Last imported at : May 31, 2023, 4 p.m. Source : ClinicalTrials.gov |
Not recruiting |
|
Study design
Last imported at : Oct. 26, 2020, 11:31 p.m. Source : ClinicalTrials.gov |
RCT |
|
Allocation
Last imported at : Oct. 26, 2020, 11:31 p.m. Source : ClinicalTrials.gov |
Randomized |
|
Design
Last imported at : Oct. 26, 2020, 11:31 p.m. Source : ClinicalTrials.gov |
Parallel |
|
Masking
Last imported at : June 16, 2021, 12:32 a.m. Source : ClinicalTrials.gov |
Open label |
|
Center
Last imported at : March 15, 2023, 4 a.m. Source : ClinicalTrials.gov |
multi-center |
|
Study aim
Last imported at : Oct. 26, 2020, 11:31 p.m. Source : ClinicalTrials.gov |
Treatment |
|
Inclusion criteria
Last imported at : Sept. 29, 2022, 6 a.m. Source : ClinicalTrials.gov |
inclusion criteria: patient with covid-19 diagnosis with laboratory confirmation within the last 30 days and age 40 years old or greater if outpatient or age 18 years old or greater if inpatient (admitted to the hospital) at time of recruitment |
|
Exclusion criteria
Last imported at : Sept. 29, 2022, 6 a.m. Source : ClinicalTrials.gov |
contraindication to arb or acei, including severe aortic stenosis and angioedema patients who are currently on active treatment with arb/acei known bilateral renal artery stenosis systolic bp ≤90 mmhg egfr<30 ml/min, if not receiving dialysis treatment k>5.5 mmol/l on screening laboratory testing recent history of dizziness, vertigo, related to hypotension or orthostatic hypotension, that can lead to contraindication to acei/arbs acute respiratory distress syndrome requiring invasive ventilation |
|
Number of arms
Last imported at : Oct. 26, 2020, 11:31 p.m. Source : ClinicalTrials.gov |
7 |
|
Funding
Last imported at : Oct. 26, 2020, 11:31 p.m. Source : ClinicalTrials.gov |
Ottawa Heart Institute Research Corporation |
|
Inclusion age min
Last imported at : Sept. 29, 2022, 6 a.m. Source : ClinicalTrials.gov |
18 |
|
Inclusion age max
Last imported at : Oct. 26, 2020, 11:31 p.m. Source : ClinicalTrials.gov |
100 |
|
Countries
Last imported at : June 16, 2021, 12:32 a.m. Source : ClinicalTrials.gov |
Brazil;Canada;Mexico |
|
Type of patients
Last imported at : Oct. 26, 2020, 11:31 p.m. Source : ClinicalTrials.gov |
Moderate/severe disease at enrollment |
|
Severity scale
Last imported at : Oct. 26, 2020, 11:31 p.m. Source : ClinicalTrials.gov |
4: Moderate/severe disease at enrollment |
|
Total sample size
Last imported at : Oct. 26, 2020, 11:31 p.m. Source : ClinicalTrials.gov |
1155 |
|
primary outcome
Last imported at : Sept. 29, 2022, 6 a.m. Source : ClinicalTrials.gov |
Death;Hospitalizations;ICU admission;Major Adverse Cardiac Events (MACE);Mechanical ventilation;Quality of life of study participants;Quality of life of study participants |
|
Notes
Last imported at : Oct. 26, 2020, 11:31 p.m. Source : ClinicalTrials.gov |
None |
|
Phase
Last imported at : Feb. 25, 2021, 7:58 p.m. Source : ClinicalTrials.gov |
Phase 3 |
|
Arms
Last imported at : Oct. 26, 2020, 11:31 p.m. Source : ClinicalTrials.gov |
[{"arm_notes": "", "treatment_id": 973, "treatment_name": "Perindopril", "treatment_type": "Cardiovascular agents", "pharmacological_treatment": "Pharmacological treatment"}, {"arm_notes": "", "treatment_id": 1061, "treatment_name": "Ramipril", "treatment_type": "Cardiovascular agents", "pharmacological_treatment": "Pharmacological treatment"}, {"arm_notes": "", "treatment_id": 460, "treatment_name": "Enalapril", "treatment_type": "Cardiovascular agents", "pharmacological_treatment": "Pharmacological treatment"}, {"arm_notes": "", "treatment_id": 248, "treatment_name": "Candesartan", "treatment_type": "Cardiovascular agents", "pharmacological_treatment": "Pharmacological treatment"}, {"arm_notes": "", "treatment_id": 1349, "treatment_name": "Valsartan", "treatment_type": "Cardiovascular agents", "pharmacological_treatment": "Pharmacological treatment"}, {"arm_notes": "", "treatment_id": 744, "treatment_name": "Losartan", "treatment_type": "Cardiovascular agents", "pharmacological_treatment": "Pharmacological treatment"}, {"arm_notes": "", "treatment_id": 2188, "treatment_name": "Standard of care", "treatment_type": "Standard of care", "pharmacological_treatment": "Standard of care"}] |