COVID-19 trials registries data warehouse

https://clinicaltrials.gov/show/NCT05517642

Not reported

Not reported

2022-08-26

Completed

RCT

Randomized

Parallel

Blind label

single-center

Prevention

inclusion criteria: participant is willing and able to give written informed consent for participation in the study. male or female, aged 18 years or above and in good health as determined by study clinician. participants may have well controlled or mild-moderate comorbidity. female participants of childbearing potential must be willing to ensure that they or their partner use effective contraception from 1 month prior to first immunisation continuously until 3 months after boost immunisation. in the investigator's opinion, participant is able and willing to comply with all trial requirements. at least 16 weeks after first booster dose of vaccination.

confirmed cases, suspected cases or asymptomatic cases of covid-19. self-reported history of sars and mers infection. receipt of live attenuated vaccine within one month prior to vaccination and other vaccines within 14 days prior to vaccination. receipt of any sars-cov-2 vaccine after first dose of booster vaccination. participants who are pregnant at enrolment or planning to become pregnant during the first 3 months following vaccination. administration of immunoglobulins and/or any blood products within the three months preceding the planned administration of the vaccines. history of allergic disease or reactions likely to be exacerbated by any component of study vaccines. any history of anaphylaxis. bleeding disorder (e.g. factor deficiency, coagulopathy or platelet disorder), or continuous use of anticoagulants (warfarin, apixaban, rivaroxaban, dabigatran, edoxaban), or prior history of significant bleeding or bruising following im injections or venipuncture. suspected or known current alcohol or drug dependency. any other significant disease, disorder or finding which may significantly increase the risk to the volunteer because of participation in the study, affect the ability of the volunteer to participate in the study or impair interpretation of the study data. severe and/or uncontrolled cardiovascular disease, respiratory disease, gastrointestinal disease, liver disease, renal disease, endocrine disorder and neurological illness (mild/moderate well controlled comorbidities are allowed). participant with life expectancy of less than 6 months.

2

CanSino Biologics Inc.

18

100

Malaysia

Healthy volunteers

N/A

540

Baseline level of Anti-Ad5 antibodies by ChemiLuminescence.;Level of anti S-RBD IgG by ELISA.;Level of pseudo neutralising antibodies against the wild-type original strain and Beta, Delta, Omicron and emerging VOCs by ELISA.;Level of saliva IgA antibodies by ELISA.;Level of serum Anti-Nucleocapsid IgG by ELISA.;Level of serum Anti-Spike IgG by ELISA.;Level of serum functional neutralizing antibodies by cPass Genscript

None

Phase 3

[{"arm_notes": "nan", "treatment_id": 222, "treatment_name": "Bnt162b2", "treatment_type": "Rna based vaccine", "pharmacological_treatment": "Vaccine"}, {"arm_notes": "nan", "treatment_id": 2066, "treatment_name": "Ad5-ncov-ih", "treatment_type": "Non replicating viral vector", "pharmacological_treatment": "Vaccine"}]