COVID-19 trials registries data warehouse

http://en.irct.ir/trial/60762

Gholamhosein Alishiri

morteza_izadi@yahoo.com

2022-07-07

Completed

RCT

Randomized

Parallel

Blind label

single-center

Treatment

Living in a family with at least one infected person with COVID-19 Not having pulmonary involvement Not having symptoms like chest wall pain and dysnea suggesting pulmonary involvement Positive PCR test of COVID-19 Patient with COVID-19 symptoms lesser than 3 days Patients satisfied with consumption of oral medication Blood oxygen saturation above 93 percents

Patients under 18 years old Having underlying diseases such as uncontrolled diabetes, uncontrolled blood pressure, liver and heart disease and kidney, heart and liver failure History of any of the diseases including hepatitis B or C, HIV, autoimmune diseases and immunodeficiency History of hepatocellular disease, liver failure and heart failure of liver tests more than 3 times normal History of allergy to antiviral drugs Existence of thrombocytopenia (platelets under 100000) History of recent COVID-19 vaccination lesser than 7 days being pregnant breastfeeding

2

Bagheiat-allah University of Medical Sciences

18

100

Iran

Mild disease at enrollment

1: Mild disease at enrollment

500

Negative pcr test or increase in CT NUMBER after intervention fever serum CRP inflammatory factor The level of oxygen saturation in the blood of patients dry cough existance dyspnea muscular pain pulse rate respiratory rate blood pressure serum ESR inflammatory factor

Phase 2/Phase 3

[{"arm_notes": "oral molnopiravir 200 mg daily for up to five days after the intervention, with diphenhydramine syrup / vitamin C tablet / vitamin D tablet / famotidine 40 mg tablet every 12 hours", "treatment_id": 813, "treatment_name": "Molnupiravir", "treatment_type": "Antivirals", "pharmacological_treatment": "Pharmacological treatment"}, {"arm_notes": " for five days, with diphenhydramine syrup, vitamin C tablets, vitamin D tablets, famotidine 40mg tablets every 12 hours, and naproxen 250 in case of fever and muscle aches. They will receive it once or twice a day", "treatment_id": 2187, "treatment_name": "Placebo", "treatment_type": "Placebo", "pharmacological_treatment": "Placebo"}]