COVID-19 trials registries data warehouse

https://clinicaltrials.gov/show/NCT04458519

Martin Y Desrosiers, MD

desrosiers_martin@hotmail.com

2020-07-07

Completed

RCT

Randomized

Parallel

Blind label

single-center

Treatment

inclusion criteria: - males and females aged 18-59 years - positive diagnosis of covid-19 infection less than 96 hours - characteristic respiratory symptoms present but no more than mild to moderate - no need for oxygen - temperature less than 38.0 ºc - not presently being considered for hospitalisation or icu admission - able to perform nasal irrigation - able to provide consent - able to communicate with the study team by phone, text or email

- patients with pre-existing conditions or demographic features placing them at increased risk of complications from covid10 infection will not be included in this study. these will be considered exclusion factors, thus individuals will be questioned as to the presence or these factors during their telephone screening. - respiratory disorders: - asthma, pre-existing copd, bronchiectasis or cystic fibrosis - hypertension - cardiovascular disease: - rhythm disturbances, recent (less than 6 months), angina pectoris cardiac insufficiency - diabetes - immunosuppressed patients (other than covid-19 induced) - primary immune deficiencies such as hypogammaglobulinemia or common variable immune deficiency (cvid) - chemotherapy depressing the immune system - immune suppressing medications such as prednisone, imuran, or tnf inhibitors, or anti-rejection transplant drugs. - solid organ transplant - cancer under treatment or within five years (except basocellular skin cancers) - pregnant or breastfeeding women or women unwilling to practice contraception as outlined in the study protocol for the duration of the study period. - allergy to milk or its derivatives

2

Centre hospitalier de l'Université de Montréal (CHUM)

18

59

Canada

Mild disease at enrollment

1: Mild disease at enrollment

23

Change in severity of COVID-19 infection

None

Not reported

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