COVID-19 trials registries data warehouse

https://clinicaltrials.gov/show/NCT04456452

Ampio Pharmaceuticals, Inc.

AP-016@ampiopharma.com

2020-07-02

Completed

RCT

Randomized

Parallel

Blind label

single-center

Treatment

inclusion criteria: male or female, 18 years to 89 years old (inclusive). hospitalized and diagnosed with covid-19, as evaluated by pcr test confirming infection with sars-cov-2. patient is receiving supplemental oxygen (e.g. oxygen saturation (spo2) <88%, labored breathing, increased respiratory rate, dyspnea on rest or exertion). a signed informed consent form from the patient or the patient's legal representative must be available.

in the opinion of the clinical team, progression to death is imminent and inevitable, irrespective of the provision of treatments. patient has severe chronic obstructive pulmonary disease (copd), chronic renal failure, or significant liver abnormality (e.g. cirrhosis, transplant, etc.). patient is on chronic immunosuppressive medication. as a result of the medical review and screening investigation, the principal investigator considers the patient unfit for the study. a history of allergic reactions to human albumin (reaction to non-human albumin such as egg albumin is not an exclusion criterion) or excipients in 5% human albumin (n-acetyltryptophan, sodium caprylate). patient has known pregnancy or is currently breastfeeding. participation in another clinical trial. baseline qt prolongation.

2

Ampio Pharmaceuticals. Inc.

18

89

United States

Moderate/severe disease at enrollment

4: Moderate/severe disease at enrollment

10

Incidence and severity of adverse events

None

Phase 1

[{"arm_notes": "", "treatment_id": 749, "treatment_name": "Low molecular weight fraction of human serum albumin (hsa)", "treatment_type": "Anti-inflammatories", "pharmacological_treatment": "Pharmacological treatment"}, {"arm_notes": "", "treatment_id": 2188, "treatment_name": "Standard of care", "treatment_type": "Standard of care", "pharmacological_treatment": "Standard of care"}]