COVID-19 trials registries data warehouse

http://en.irct.ir/trial/49277

Dr. Seyyed Abbas Motevalian

research-m@iums.ac.ir

2020-08-16

Completed

RCT

Randomized

Parallel

Open label

single-center

Treatment

admitted patients with COVID-19 moderate to severe, stable patients

unstable and intubated ICU patients pregnancy, breastfeeding infancy allergy and intolerance to NAC unstable vital signs or need for intubation

2

Iran University of Medical Sciences

0

100

Iran

Moderate/severe disease at enrollment

4: Moderate/severe disease at enrollment

60

Time to improve symptoms such as cough, shortness of breath and lethargy O2 saturation Re-hospitalization after discharge duration of hospitalization Evaluation of laboratory parameters as a series of factors: PCR and LDH, CBC, ESR, CRP Comparison of parameters at the beginning of hospitalization, during hospitalization and at the time of discharge Check for changes in anti-inflammatory parameters (TNF-ALPHA and IL-6 if measuring kits are available) Investigation of radiological changes at the beginning of hospitalization and during hospitalization if possible ICU admission recovery or death

Phase 3

[{"arm_notes": "", "treatment_id": 850, "treatment_name": "N-acetylcysteine", "treatment_type": "Respiratory agents", "pharmacological_treatment": "Pharmacological treatment"}, {"arm_notes": "", "treatment_id": 2188, "treatment_name": "Standard of care", "treatment_type": "Standard of care", "pharmacological_treatment": "Standard of care"}]