COVID-19 trials registries data warehouse

http://en.irct.ir/trial/47031

Maria Tavakoli Ardakani

info@sbmu.ac.ir

2020-08-17

Completed

RCT

Randomized

Parallel

Blind label

single-center

Treatment

Virological diagnosis of SARS-CoV-2 infection by RT-PCR Positive imaging findings: Condensation, Grand Glass opacity or bilateral pulmonary infiltration on CT scan or Chest X-ray Need to get extra oxygen to maintain SO2> 94% or PaO2 / FiO2> 300

Age less than 18 years The patient has septic shock Pregnancy and lactation The patient is intubated and under mechanical ventilation The patient was admitted to the ICU Having an allergy to curcumin

2

Shahid Beheshti University of Medical Sciences

18

100

Iran

Moderate/severe disease at enrollment

4: Moderate/severe disease at enrollment

20

1- Evaluation of clinical variables involved in patients' recovery including mechanical ventilation 2- Organ failure and comparison of these results in the two groups of treatment and control 3- Mortality and comparison of these results in the two groups of treatment and control 4- The length of hospital stay and comparison of these results in the treatment and controlgroups 5- Length of ICU hospitalization and comparison of these results in the treatment and controlgroups 6- Receiving oxygen and comparing these results in the treatment and control groups 7- The length of the negative period of PCR test and comparison of these results in thetreatment and control groups 8- Comparison of interleukin-6 levels in the treatment and control groups 9- Comparison of patients' ferritin levels in treatment and control groups 10- Comparison of patients' CRP levels in treatment and control groups 11- Length of improvement period of patients' lung imaging results and comparison of results intreatment and control groups 12- Lymphocyte count and comparison of results in treatment and control groups 13- Length of respiratory symptoms and comparison of results between treatment and controlgroups

Phase 3

[{"arm_notes": "", "treatment_id": 362, "treatment_name": "Curcumin", "treatment_type": "Vitamins and dietary supplements", "pharmacological_treatment": "Pharmacological treatment"}, {"arm_notes": "", "treatment_id": 2187, "treatment_name": "Placebo", "treatment_type": "Placebo", "pharmacological_treatment": "Placebo"}]