COVID-19 trials registries data warehouse

http://ensaiosclinicos.gov.br/rg/RBR-3f8dm6q

Ícaro Pires

icaroatp@gmail.com

2022-01-23

Not recruiting

RCT

Randomized

Parallel

Open label

unclear

Long covid

Patients who complain of anosmia or hyposmia after SARS-CoV-2 infection less than 3 months after symptom onset, convalescing from her COVID-19 disease, with onset of disease symptoms for at least 4 weeks, Patients who underwent RT-PCR test at symptom onset, with detection of SARS-CoV-2, Patients who can give valid written informed consent, Patients motivated to participate in the study, Adult patients aged 18-60 years.

Patients who cannot give valid written informed consent, Patients with a previous history of more than one SARS-CoV-2 infection Patients with nasosinusal diseases such as chronic rhinosinusitis or nasal masses, History of previous traumatic brain injury with olfactory sequelae, History of olfaction disorder prior to SARS CoV-2 infection, Patients with any diagnosed neurological disease known to affect olfactory function, Patients unable to read Portuguese, Patients who are already using an oral glucocorticoid, Patients who have already started some form of therapy for the olfactory disorder caused by COVID-19, Known hypersensitivity to any item used in any of the proposed olfactory training,

2

Complexo Hospital de Clínicas da Universidade Federal do Paraná

18

60

Brazil

Patients recovered from covid

N/A

0

The primary outcome assessed will be improvement in olfaction (periods 4; 12; 24 and 52 weeks after starting treatment). The evaluation of smell is based on the comparison of results from before and after the olfactory rehabilitation obtained from a single method of the two methods: olfactory identification results obtained from the University of Pennsylvania Smell Identification Test (UPSIT); Subjective assessment of patients using a visual analogue scale for the following complaints: loss of ability to smell; loss of ability to sense flavors; nasal symptoms in the last 14 days; how much the difficulty in smelling bothers; how much the difficulty in feeling flavors bothers.

Not reported

[{"arm_notes": "", "treatment_id": 2163, "treatment_name": "Modified olfactory training (12 essential oils)", "treatment_type": "Olfactory training", "pharmacological_treatment": "Non pharmacological treatment"}, {"arm_notes": "", "treatment_id": 919, "treatment_name": "Olfactory training", "treatment_type": "Olfactory training", "pharmacological_treatment": "Non pharmacological treatment"}]