COVID-19 trials registries data warehouse

https://www.thaiclinicaltrials.org/show/TCTR20210714006

Jidapa Tragoonrungsea

janjy.t@gmail.com

2021-07-14

Recruiting

RCT

Randomized

Parallel

Open label

single-center

Treatment

1. Age &gt,18 years 2. Confirmed COVID-19 test positive with new onset of smell dysfunction 3. Patients who capable to perform nasal irrigation themselves

1. Chronic use of nasal or systemic corticosteroids 2. History of smell loss before COVID-19 era 3. Previous history of rhinological diseases such as chronic rhinosinustis, nasal tumor, anatomical abnormalities of the nose 4. Pregnancy 5. The patients who refuse to enroll the study.

2

N/A

18

100

Thailand

Mild disease at enrollment

1: Mild disease at enrollment

200

Smell sensation at baseline; post-irrigation 1 week; 2 weeks; 3 weeks; 4 weeks and 6 weeks. VAS score -VAS will be graded by patients which zero is completely normal smell sensation and ten is total loss of smell. ;Smell perception of specific odors (fish sauce; orange; coffee and jasmine ) at baseline; post-irrigation 1 week; 2 weeks; 3 weeks; 4 weeks and 6 weeks. Total Visual analog scale (VAS score) of smell perception of specific odors including 4 well-recognized odors for the Thai population. Specific odors include fish sauce; orange; coffee and jasmine ;Time to correct identification more than75% of odors and number of odors identification at each follow-up among each group baseline; post-irrigation 1 week; 2 weeks; 3 weeks; 4weeks and 6 weeks. Identification of 4 well-recognized odors for the Thai population will be assessed to evaluate time to recovery and number of odors identification at each follow-up among each group

Phase 3

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