COVID-19 trials registries data warehouse

https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=13432

James Arkinstall

media@dndi.org

2020-10-14

Recruiting

RCT

Randomized

Parallel

Open label

multi-center

Treatment

For Index Cases (treated patients from the ANTICOV Study) 1. Comes from household in accessible area 2. At least 1 Household Contact (HHC) currently residing at household with index 3. Contact details of HHC provided by index case 4. Majority (over 50%) of HHC provide consent and enrol in the ANTICOV-EPI study 5. Randomised to ANTICOV For Household contacts (not treated patients living with the Index patient) 6. Member of same household as index case (household defined as sharing same cooking area) during the conduct of the study 7. Resides in household with index case before index case illness onset. 8. Majority (over 50%) of HHC provide consent and enrol in the ANTICOV-EPI study

Exclusion criteria of household contacts 1. Inability to provide consent 2. Majority of all contacts of index in household do not enroll

3

DNDi

0

100

Equatorial Guinea;Ghana;Kenya;Mozambique

Mild/moderate disease at enrollment

2: Mild/moderate disease at enrollment

1500

1) Seroconversion for SARS-CoV-2 IgM; IgA and IgG among household contacts and index case;2) RT-PCR SARS-CoV-2 positive results at Day 1 (index case)/D2(household contacts); 7; 14; 21; and Month 1 in household contacts and index case.;3) Secondary attack rate of infection and illness for household contacts from index cases

| Declared number of arm (3.0) differs from found arms (4.0)

Phase 3

[{"arm_notes": "", "treatment_id": 607, "treatment_name": "Hydroxychloroquine", "treatment_type": "Antimalarials", "pharmacological_treatment": "Pharmacological treatment"}, {"arm_notes": "", "treatment_id": 958, "treatment_name": "Paracetamol", "treatment_type": "Central nervous system agents", "pharmacological_treatment": "Pharmacological treatment"}, {"arm_notes": "", "treatment_id": 1604, "treatment_name": "Lopinavir+ritonavir", "treatment_type": "Antivirals", "pharmacological_treatment": "Pharmacological treatment"}]