COVID-19 trials registries data warehouse

https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=11103

MIORAMALALA Sedera

sedera.mioramalala@gmail.com

2020-05-29

Not recruiting

RCT

Randomized

Factorial

Blind label

single-center

Treatment

Adults aged between 18 to 70 • COVID-19 confirmed by a RT-PCR test in real time 4 days before being enrolled in the clinical trial • Patients with moderate signs of COVID-19 • Patients consenting voluntarily and freely

Contraindications to the drug tested • Patients who require breathing apparatus (eg invasive ventilation, invasive mechanical ventilation, oxygenation of the extra-corporeal membrane) • Patients who participated in other clinical trials related to COVID-19 • Patients who received medication directly treating COVID-19 24 hours before the start of the study.

3

Malagasy government

18

70

Madagascar

Moderate disease at enrollment

3: Moderate disease at enrollment

60

This project will provide a better understanding of the efficacy of Artesunate IV alone or combined with Vitamin C in the form of Na-ascorbate compared to ISS in Madagascar in order to develop new strategies for the management of covid -19 adapted to the local context.

| Declared number of arm (3.0) differs from found arms (4.0)

Phase 2

[{"arm_notes": "", "treatment_id": 121, "treatment_name": "Artesunate", "treatment_type": "Antimalarials", "pharmacological_treatment": "Pharmacological treatment"}, {"arm_notes": "", "treatment_id": 1411, "treatment_name": "Artesunate+vitamin c", "treatment_type": "Antimalarials+vitamins and dietary supplements", "pharmacological_treatment": "Pharmacological treatment"}, {"arm_notes": "", "treatment_id": 2187, "treatment_name": "Placebo", "treatment_type": "Placebo", "pharmacological_treatment": "Placebo"}]