inclusion criteria: * be at least 18 years of age at time of informed consent * diagnosis of active sars cov 2 infection using viral rna or viral antigen within 7 days of screening * respiratory failure requiring oxygen supplementation or either invasive or noninvasive mechanical ventilation with pao2/fio2 ratio \>100 mm hg. respiratory failure cannot be fully explained by cardiac failure or fluid overload.

inclusion criteria: * be at least 18 years of age at time of informed consent * diagnosis of active sars cov 2 infection using viral rna or viral antigen within 7 days of screening * respiratory failure requiring oxygen supplementation or either invasive or noninvasive mechanical ventilation with pao2/fio2 ratio \>100 mm hg. respiratory failure cannot be fully explained by cardiac failure or fluid overload.

inclusion criteria: - be at least 18 years of age at time of informed consent - diagnosis of active sars cov 2 infection using viral rna or viral antigen within 7 days of screening respiratory failure requiring oxygen supplementation or either invasive or noninvasive mechanical ventilation with pao2/fio2 ratio >100 mm hg. respiratory failure cannot be fully explained by cardiac failure or fluid overload.

inclusion criteria: - be at least 18 years of age at time of informed consent - diagnosis of active sars cov 2 infection using viral rna or viral antigen within 7 days of screening respiratory failure requiring oxygen supplementation or either invasive or noninvasive mechanical ventilation with pao2/fio2 ratio >100 mm hg. respiratory failure cannot be fully explained by cardiac failure or fluid overload.