inclusion criteria: 1. men and women ≥18 years of age at the time of consent. 2. laboratory-confirmed diagnosis of covid-19. 3. hospitalized for covid-19 related respiratory disease. 4. patient belongs to one of the following two categories in the nine-point covid-19 severity scale: 1. hospitalized, requiring intubation and mechanical ventilation - level 6 of the nine-point covid-19 severity scale. 2. hospitalized and intubated with additional organ support - pressors, rrt, ecmo - level 7 of the nine-point covid-19 severity scale. 5. for women of childbearing potential involved in any sexual intercourse that could lead to pregnancy: negative pregnancy test and willingness to use contraceptive (consistent with local regulations) during the study period. 6. signed informed consent obtained by any patient capable of giving consent, or, when the patient is not capable of giving consent, from his or her legal/authorized representatives.

inclusion criteria: 1. men and women ≥18 years of age at the time of consent. 2. laboratory-confirmed diagnosis of covid-19. 3. hospitalized for covid-19 related respiratory disease. 4. patient belongs to one of the following two categories in the nine-point covid-19 severity scale: 1. hospitalized, requiring intubation and mechanical ventilation - level 6 of the nine-point covid-19 severity scale. 2. hospitalized and intubated with additional organ support - pressors, rrt, ecmo - level 7 of the nine-point covid-19 severity scale. 5. for women of childbearing potential involved in any sexual intercourse that could lead to pregnancy: negative pregnancy test and willingness to use contraceptive (consistent with local regulations) during the study period. 6. signed informed consent obtained by any patient capable of giving consent, or, when the patient is not capable of giving consent, from his or her legal/authorized representatives.

inclusion criteria: men and women ≥18 years of age at the time of consent. laboratory-confirmed diagnosis of covid-19. hospitalized for covid-19 related respiratory disease. patient belongs to one of the following two categories in the nine-point covid-19 severity scale: hospitalized, requiring intubation and mechanical ventilation - level 6 of the nine-point covid-19 severity scale. hospitalized and intubated with additional organ support - pressors, rrt, ecmo - level 7 of the nine-point covid-19 severity scale. for women of childbearing potential involved in any sexual intercourse that could lead to pregnancy: negative pregnancy test and willingness to use contraceptive (consistent with local regulations) during the study period. signed informed consent obtained by any patient capable of giving consent, or, when the patient is not capable of giving consent, from his or her legal/authorized representatives.

inclusion criteria: men and women ≥18 years of age at the time of consent. laboratory-confirmed diagnosis of covid-19. hospitalized for covid-19 related respiratory disease. patient belongs to one of the following two categories in the nine-point covid-19 severity scale: hospitalized, requiring intubation and mechanical ventilation - level 6 of the nine-point covid-19 severity scale. hospitalized and intubated with additional organ support - pressors, rrt, ecmo - level 7 of the nine-point covid-19 severity scale. for women of childbearing potential involved in any sexual intercourse that could lead to pregnancy: negative pregnancy test and willingness to use contraceptive (consistent with local regulations) during the study period. signed informed consent obtained by any patient capable of giving consent, or, when the patient is not capable of giving consent, from his or her legal/authorized representatives.

inclusion criteria: men and women ≥18 years of age at the time of consent. laboratory-confirmed diagnosis of covid-19. hospitalized for covid-19 related respiratory disease. patient belongs to one of the following four categories in the nine-point covid-19 severity scale: hospitalized, not requiring supplemental oxygen - level 3 of the nine-point covid-19 severity scale. hospitalized, requiring supplemental oxygen - level 4 of the nine-point covid-19 severity scale. hospitalized, requiring nasal high-flow oxygen therapy, non-invasive mechanical ventilation, or both - level 5 of the nine-point covid-19 severity scale. hospitalized, requiring intubation and mechanical ventilation- level 6 of the nine-point covid-19 severity scale. for women of childbearing potential involved in any sexual intercourse that could lead to pregnancy: negative pregnancy test and willingness to use contraceptive (consistent with local regulations) during the study period. signed informed consent form by any patient capable of giving consent, or, when the patient is not capable of giving consent, by his or her legal/authorized representatives.

inclusion criteria: men and women ≥18 years of age at the time of consent. laboratory-confirmed diagnosis of covid-19. hospitalized for covid-19 related respiratory disease. patient belongs to one of the following four categories in the nine-point covid-19 severity scale: hospitalized, not requiring supplemental oxygen - level 3 of the nine-point covid-19 severity scale. hospitalized, requiring supplemental oxygen - level 4 of the nine-point covid-19 severity scale. hospitalized, requiring nasal high-flow oxygen therapy, non-invasive mechanical ventilation, or both - level 5 of the nine-point covid-19 severity scale. hospitalized, requiring intubation and mechanical ventilation- level 6 of the nine-point covid-19 severity scale. for women of childbearing potential involved in any sexual intercourse that could lead to pregnancy: negative pregnancy test and willingness to use contraceptive (consistent with local regulations) during the study period. signed informed consent form by any patient capable of giving consent, or, when the patient is not capable of giving consent, by his or her legal/authorized representatives.

inclusion criteria: 1. men and women ≥18 years of age at the time of consent. 2. laboratory-confirmed diagnosis of covid-19. 3. hospitalized for covid-19 related respiratory disease. 4. patient belongs to one of the following four categories in the nine-point covid-19 severity scale: 1. hospitalized, not requiring supplemental oxygen - level 3 of the nine-point covid-19 severity scale. 2. hospitalized, requiring supplemental oxygen - level 4 of the nine-point covid-19 severity scale. 3. hospitalized, requiring nasal high-flow oxygen therapy, non-invasive mechanical ventilation, or both - level 5 of the nine-point covid-19 severity scale. 4. hospitalized, requiring intubation and mechanical ventilation- level 6 of the nine-point covid-19 severity scale. 5. for women of childbearing potential involved in any sexual intercourse that could lead to pregnancy: negative pregnancy test and willingness to use contraceptive (consistent with local regulations) during the study period. 6. signed informed consent form by any patient capable of giving consent, or, when the patient is not capable of giving consent, by his or her legal/authorized representatives.

inclusion criteria: 1. men and women ≥18 years of age at the time of consent. 2. laboratory-confirmed diagnosis of covid-19. 3. hospitalized for covid-19 related respiratory disease. 4. patient belongs to one of the following four categories in the nine-point covid-19 severity scale: 1. hospitalized, not requiring supplemental oxygen - level 3 of the nine-point covid-19 severity scale. 2. hospitalized, requiring supplemental oxygen - level 4 of the nine-point covid-19 severity scale. 3. hospitalized, requiring nasal high-flow oxygen therapy, non-invasive mechanical ventilation, or both - level 5 of the nine-point covid-19 severity scale. 4. hospitalized, requiring intubation and mechanical ventilation- level 6 of the nine-point covid-19 severity scale. 5. for women of childbearing potential involved in any sexual intercourse that could lead to pregnancy: negative pregnancy test and willingness to use contraceptive (consistent with local regulations) during the study period. 6. signed informed consent form by any patient capable of giving consent, or, when the patient is not capable of giving consent, by his or her legal/authorized representatives.

inclusion criteria: 1. men and women between ≥18 years of age at the time of consent. 2. laboratory-confirmed diagnosis of covid-19 3. hospitalized for covid-19 related respiratory disease as indicated by one of the following: 1. sao2 /spo2≤94% on ambient air or pao2/fio2 <300 mmhg/40 kpa 2. chest imaging findings compatible with covid-19 pneumonia 4. patient belongs to one of the following three categories in the seven-point covid-19 severity scale: 1. requiring supplemental oxygen - level 4 of the seven-point covid-19 severity scale. 2. requiring nasal high-flow oxygen therapy, non-invasive mechanical ventilation, or both - level 5 of the seven-point covid-19 severity scale. 3. hospitalized, requiring venovenous extracorporeal membrane oxygenation (ecmo), invasive mechanical ventilation, or both - level 6 of the seven-point covid-19 severity scale. 5. for women of childbearing potential involved in any sexual intercourse that could lead to pregnancy: negative pregnancy test and willingness to use contraceptive (consistent with local regulations) during the study period. 6. signed informed consent form by any patient capable of giving consent, or, when the patient is not capable of giving consent, by his or her legal/authorized representatives.

inclusion criteria: 1. men and women between ≥18 years of age at the time of consent. 2. laboratory-confirmed diagnosis of covid-19 3. hospitalized for covid-19 related respiratory disease as indicated by one of the following: 1. sao2 /spo2≤94% on ambient air or pao2/fio2 <300 mmhg/40 kpa 2. chest imaging findings compatible with covid-19 pneumonia 4. patient belongs to one of the following three categories in the seven-point covid-19 severity scale: 1. requiring supplemental oxygen - level 4 of the seven-point covid-19 severity scale. 2. requiring nasal high-flow oxygen therapy, non-invasive mechanical ventilation, or both - level 5 of the seven-point covid-19 severity scale. 3. hospitalized, requiring venovenous extracorporeal membrane oxygenation (ecmo), invasive mechanical ventilation, or both - level 6 of the seven-point covid-19 severity scale. 5. for women of childbearing potential involved in any sexual intercourse that could lead to pregnancy: negative pregnancy test and willingness to use contraceptive (consistent with local regulations) during the study period. 6. signed informed consent form by any patient capable of giving consent, or, when the patient is not capable of giving consent, by his or her legal/authorized representatives.