1. Refusal to participate <br/ >2. Moribund patients with life expectancy less than 48h <br/ >3. Pregnancy <br/ >4. Patients requiring more than 20mcg/min of noradrenalin support or equivalent dose of another inotropes/ vasopressor <br/ >5. Co-existing chronic obstructive pulmonary disease <br/ >6. Co- existing Neuro-muscular diseases <br/ >7. Recruitment in another randomized trial <br/ >

1. Refusal to participate <br/ >2. Moribund patients with life expectancy less than 48h <br/ >3. Pregnancy <br/ >4. Patients requiring more than 20mcg/min of noradrenalin support or equivalent dose of another inotropes/ vasopressor <br/ >5. Co-existing chronic obstructive pulmonary disease <br/ >6. Co- existing Neuro-muscular diseases <br/ >7. Recruitment in another randomized trial <br/ >

N/A

N/A

1. Refusal to participate <br/ >2. Moribund patients with life expectancy less than 48h <br/ >3. Pregnancy <br/ >4. Patients requiring more than 20mcg/min of noradrenalin support or equivalent dose of another inotropes/ vasopressor <br/ >5. Co-existing chronic obstructive pulmonary disease <br/ >6. Co- existing Neuro-muscular diseases <br/ >7. Recruitment in another randomized trial <br/ >

1. Refusal to participate <br/ >2. Moribund patients with life expectancy less than 48h <br/ >3. Pregnancy <br/ >4. Patients requiring more than 20mcg/min of noradrenalin support or equivalent dose of another inotropes/ vasopressor <br/ >5. Co-existing chronic obstructive pulmonary disease <br/ >6. Co- existing Neuro-muscular diseases <br/ >7. Recruitment in another randomized trial <br/ >