inclusion criteria: 1. signed informed consent 2. negative pregnancy test in women 3. covid-19 confirmed by rtpcr in any respiratory sample. 4. severe covid-19 disease defined as any from the following: 1. pulse oximetry less than 91% or a 3% drop from base pulse oximetry or need to increase supplementary oxygen in chronic hypoxia 2. need for mechanical ventilation (invasive or non invasive ) 3. sepsis/septic shock.

inclusion criteria: 1. signed informed consent 2. negative pregnancy test in women 3. covid-19 confirmed by rtpcr in any respiratory sample. 4. severe covid-19 disease defined as any from the following: 1. pulse oximetry less than 91% or a 3% drop from base pulse oximetry or need to increase supplementary oxygen in chronic hypoxia 2. need for mechanical ventilation (invasive or non invasive ) 3. sepsis/septic shock.

inclusion criteria: signed informed consent negative pregnancy test in women covid-19 confirmed by rtpcr in any respiratory sample. severe covid-19 disease defined as any from the following: pulse oximetry less than 91% or a 3% drop from base pulse oximetry or need to increase supplementary oxygen in chronic hypoxia need for mechanical ventilation (invasive or non invasive ) sepsis/septic shock.

inclusion criteria: signed informed consent negative pregnancy test in women covid-19 confirmed by rtpcr in any respiratory sample. severe covid-19 disease defined as any from the following: pulse oximetry less than 91% or a 3% drop from base pulse oximetry or need to increase supplementary oxygen in chronic hypoxia need for mechanical ventilation (invasive or non invasive ) sepsis/septic shock.

inclusion criteria: 1. signed informed consent 2. negative pregnancy test in women 3. covid-19 confirmed by rtpcr in any respiratory sample. 4. severe covid-19 disease defined as any from the following: 1. pulse oximetry less than 91% or a 3% drop from base pulse oximetry or need to increase supplementary oxygen in chronic hypoxia 2. need for mechanical ventilation (invasive or non invasive ) 3. sepsis/septic shock.

inclusion criteria: 1. signed informed consent 2. negative pregnancy test in women 3. covid-19 confirmed by rtpcr in any respiratory sample. 4. severe covid-19 disease defined as any from the following: 1. pulse oximetry less than 91% or a 3% drop from base pulse oximetry or need to increase supplementary oxygen in chronic hypoxia 2. need for mechanical ventilation (invasive or non invasive ) 3. sepsis/septic shock.