[{"arm_notes": "", "treatment_id": null, "treatment_name": "Intervention1: High Flow Nasal Oxygen therapy: Patients allocated to HFNO arm will be applied HFNO through large-bore binasal prongs with a high flow heated humidifier device (Optiflow; Fisher and Paykel Healthcare). The initial gas flow rate will be 50 liters per minute and an FIO2 of 1.0. The flow and FiO2 subsequently adjusted between @ 30 \u00e2?? 60L/min and 0.5 -1.0 respectively to maintain SpO2 of 94% or more.Control Intervention1: Non invasive ventilation: Patients allocated to NIV arm will be applied to NIV with either mask/helmet device connected to an ICU ventilator with the setting of PS 10-20 cmH2O adjusted with the aim of obtaining an expired tidal volume of 7 to 10 ml per kilogram of predicted body weight and PEEP 5-10cmH2O titrated to target SpO2 94%.", "treatment_type": "TODO", "pharmacological_treatment": "TODO"}, {"arm_notes": "", "treatment_id": null, "treatment_name": "Intervention1: High Flow Nasal Oxygen therapy: Patients allocated to HFNO arm will be applied HFNO through large-bore binasal prongs with a high flow heated humidifier device (Optiflow; Fisher and Paykel Healthcare). The initial gas flow rate will be 50 liters per minute and an FIO2 of 1.0. The flow and FiO2 subsequently adjusted between @ 30 \u00e2?? 60L/min and 0.5 -1.0 respectively to maintain SpO2 of 94% or more.", "treatment_type": "TODO", "pharmacological_treatment": "TODO"}, {"arm_notes": "", "treatment_id": null, "treatment_name": "Control Intervention1: Non invasive ventilation: Patients allocated to NIV arm will be applied to NIV with either mask/helmet device connected to an ICU ventilator with the setting of PS 10-20 cmH2O adjusted with the aim of obtaining an expired tidal volume of 7 to 10 ml per kilogram of predicted body weight and PEEP 5-10cmH2O titrated to target SpO2 94%.", "treatment_type": "TODO", "pharmacological_treatment": "TODO"}]

[{"arm_notes": "", "treatment_id": 577, "treatment_name": "High flow nasal oxygen", "treatment_type": "Respiratory support", "pharmacological_treatment": "Non pharmacological treatment"}, {"arm_notes": "", "treatment_id": 2188, "treatment_name": "Standard of care", "treatment_type": "Standard of care", "pharmacological_treatment": "Standard of care"}]

[{"arm_notes": "", "treatment_id": null, "treatment_name": "N/A", "treatment_type": "TODO", "pharmacological_treatment": "TODO"}]

[{"arm_notes": "", "treatment_id": null, "treatment_name": "Intervention1: High Flow Nasal Oxygen therapy: Patients allocated to HFNO arm will be applied HFNO through large-bore binasal prongs with a high flow heated humidifier device (Optiflow; Fisher and Paykel Healthcare). The initial gas flow rate will be 50 liters per minute and an FIO2 of 1.0. The flow and FiO2 subsequently adjusted between @ 30 \u00e2?? 60L/min and 0.5 -1.0 respectively to maintain SpO2 of 94% or more.Control Intervention1: Non invasive ventilation: Patients allocated to NIV arm will be applied to NIV with either mask/helmet device connected to an ICU ventilator with the setting of PS 10-20 cmH2O adjusted with the aim of obtaining an expired tidal volume of 7 to 10 ml per kilogram of predicted body weight and PEEP 5-10cmH2O titrated to target SpO2 94%.", "treatment_type": "TODO", "pharmacological_treatment": "TODO"}, {"arm_notes": "", "treatment_id": null, "treatment_name": "Intervention1: High Flow Nasal Oxygen therapy: Patients allocated to HFNO arm will be applied HFNO through large-bore binasal prongs with a high flow heated humidifier device (Optiflow; Fisher and Paykel Healthcare). The initial gas flow rate will be 50 liters per minute and an FIO2 of 1.0. The flow and FiO2 subsequently adjusted between @ 30 \u00e2?? 60L/min and 0.5 -1.0 respectively to maintain SpO2 of 94% or more.", "treatment_type": "TODO", "pharmacological_treatment": "TODO"}, {"arm_notes": "", "treatment_id": null, "treatment_name": "Control Intervention1: Non invasive ventilation: Patients allocated to NIV arm will be applied to NIV with either mask/helmet device connected to an ICU ventilator with the setting of PS 10-20 cmH2O adjusted with the aim of obtaining an expired tidal volume of 7 to 10 ml per kilogram of predicted body weight and PEEP 5-10cmH2O titrated to target SpO2 94%.", "treatment_type": "TODO", "pharmacological_treatment": "TODO"}]