inclusion criteria: 1. the patient or legally authorized representative (lar) must have the ability to understand and the willingness to provide a signed and dated informed consent form. 2. age 18 years and over 3. the patient agrees to use adequate contraception for the duration of the treatment protocol and for 6 months post treatment. 4. positive rt- pcr testing for covid-19 nucleic acid using nasopharyngeal swabbing or any other site 5. patient meets ards criteria and is on non-invasive or mechanical ventilation or high flow nasal cannula 1. bilateral opacities on chest imaging consistent with pulmonary edema 2. a need for positive pressure ventilation or high flow nasal cannula 3. pao2/fio2 ratio ≤ 300 mmhg by arterial blood gas or spo2/fio2 imputation. 4. infiltrates not fully explained by cardiac failure or fluid overload in the physician's best clinical judgement 6. subjects requiring dialysis as a result of a covid-19 infection will not be excluded.

inclusion criteria: 1. the patient or legally authorized representative (lar) must have the ability to understand and the willingness to provide a signed and dated informed consent form. 2. age 18 years and over 3. the patient agrees to use adequate contraception for the duration of the treatment protocol and for 6 months post treatment. 4. positive rt- pcr testing for covid-19 nucleic acid using nasopharyngeal swabbing or any other site 5. patient meets ards criteria and is on non-invasive or mechanical ventilation or high flow nasal cannula 1. bilateral opacities on chest imaging consistent with pulmonary edema 2. a need for positive pressure ventilation or high flow nasal cannula 3. pao2/fio2 ratio ≤ 300 mmhg by arterial blood gas or spo2/fio2 imputation. 4. infiltrates not fully explained by cardiac failure or fluid overload in the physician's best clinical judgement 6. subjects requiring dialysis as a result of a covid-19 infection will not be excluded.

inclusion criteria: the patient or legally authorized representative (lar) must have the ability to understand and the willingness to provide a signed and dated informed consent form. age 18 years and over the patient agrees to use adequate contraception for the duration of the treatment protocol and for 6 months post treatment. positive rt- pcr testing for covid-19 nucleic acid using nasopharyngeal swabbing or any other site patient meets ards criteria and is on non-invasive or mechanical ventilation or high flow nasal cannula bilateral opacities on chest imaging consistent with pulmonary edema a need for positive pressure ventilation or high flow nasal cannula pao2/fio2 ratio ≤ 300 mmhg by arterial blood gas or spo2/fio2 imputation. infiltrates not fully explained by cardiac failure or fluid overload in the physician's best clinical judgement subjects requiring dialysis as a result of a covid-19 infection will not be excluded.

inclusion criteria: the patient or legally authorized representative (lar) must have the ability to understand and the willingness to provide a signed and dated informed consent form. age 18 years and over the patient agrees to use adequate contraception for the duration of the treatment protocol and for 6 months post treatment. positive rt- pcr testing for covid-19 nucleic acid using nasopharyngeal swabbing or any other site patient meets ards criteria and is on non-invasive or mechanical ventilation or high flow nasal cannula bilateral opacities on chest imaging consistent with pulmonary edema a need for positive pressure ventilation or high flow nasal cannula pao2/fio2 ratio ≤ 300 mmhg by arterial blood gas or spo2/fio2 imputation. infiltrates not fully explained by cardiac failure or fluid overload in the physician's best clinical judgement subjects requiring dialysis as a result of a covid-19 infection will not be excluded.

inclusion criteria: 1. the patient or legally authorized representative (lar) must have the ability to understand and the willingness to provide a signed and dated informed consent form. 2. age 18 years and over 3. the patient agrees to use adequate contraception for the duration of the treatment protocol and for 6 months post treatment. 4. positive rt- pcr testing for covid-19 nucleic acid using nasopharyngeal swabbing or any other site 5. patient meets ards criteria and is on non-invasive or mechanical ventilation or high flow nasal cannula 1. bilateral opacities on chest imaging consistent with pulmonary edema 2. a need for positive pressure ventilation or high flow nasal cannula 3. pao2/fio2 ratio ≤ 300 mmhg by arterial blood gas or spo2/fio2 imputation. 4. infiltrates not fully explained by cardiac failure or fluid overload in the physician's best clinical judgement 6. subjects requiring dialysis as a result of a covid-19 infection will not be excluded.

inclusion criteria: 1. the patient or legally authorized representative (lar) must have the ability to understand and the willingness to provide a signed and dated informed consent form. 2. age 18 years and over 3. the patient agrees to use adequate contraception for the duration of the treatment protocol and for 6 months post treatment. 4. positive rt- pcr testing for covid-19 nucleic acid using nasopharyngeal swabbing or any other site 5. patient meets ards criteria and is on non-invasive or mechanical ventilation or high flow nasal cannula 1. bilateral opacities on chest imaging consistent with pulmonary edema 2. a need for positive pressure ventilation or high flow nasal cannula 3. pao2/fio2 ratio ≤ 300 mmhg by arterial blood gas or spo2/fio2 imputation. 4. infiltrates not fully explained by cardiac failure or fluid overload in the physician's best clinical judgement 6. subjects requiring dialysis as a result of a covid-19 infection will not be excluded.

inclusion criteria: 1. the patient or legally authorized representative (lar) must have the ability to understand and the willingness to provide a signed and dated informed consent form. 2. age 18 years and over 3. the patient agrees to use adequate contraception for the duration of the treatment protocol and for 6 months post treatment. 4. positive rt- pcr testing for covid-19 nucleic acid using nasopharyngeal swabbing or any other site 5. patient meets ards criteria as defined by berlin criteria, and is on mechanical ventilation a. berlin criteria for ards are: i. bilateral opacities on chest imaging consistent with pulmonary edema ii. a need for positive pressure ventilation via endotracheal or tracheostomy tube iii. pao2/fio2 ratio ≤ 300mmhg with a minimum of 5 cmh20 peep iv. infiltrates not fully explained by cardiac failure or fluid overload in the physician's best clinical judgement ards onset is considered the time that the last of criteria 1-4 is met. infiltrates considered "consistent with pulmonary edema" include any infiltrate not due to mass, atelectasis, or effusion, or opacities known to be chronic (greater than 1 week old). vascular redistribution or indistinct vessels or heart border alone do not qualify as opacities.

inclusion criteria: 1. the patient or legally authorized representative (lar) must have the ability to understand and the willingness to provide a signed and dated informed consent form. 2. age 18 years and over 3. the patient agrees to use adequate contraception for the duration of the treatment protocol and for 6 months post treatment. 4. positive rt- pcr testing for covid-19 nucleic acid using nasopharyngeal swabbing or any other site 5. patient meets ards criteria as defined by berlin criteria, and is on mechanical ventilation a. berlin criteria for ards are: i. bilateral opacities on chest imaging consistent with pulmonary edema ii. a need for positive pressure ventilation via endotracheal or tracheostomy tube iii. pao2/fio2 ratio ≤ 300mmhg with a minimum of 5 cmh20 peep iv. infiltrates not fully explained by cardiac failure or fluid overload in the physician's best clinical judgement ards onset is considered the time that the last of criteria 1-4 is met. infiltrates considered "consistent with pulmonary edema" include any infiltrate not due to mass, atelectasis, or effusion, or opacities known to be chronic (greater than 1 week old). vascular redistribution or indistinct vessels or heart border alone do not qualify as opacities.