inclusion criteria: 1. male or female patients age 18 to 85, inclusive 2. confirmed positive test for covid-19 by standard reverse transcriptase polymerase chain reaction (rt-pcr) assay or equivalent 3. on mechanical ventilation (n=35), or high-flow o2 support (n=35) and: 1. disease severity level of "moderate" (pao2/fio2 of 100-200) (n=35), or "severe" (pao2/fio2 \< 100) (n=35) as established using the berlin criteria for ards (barbas, isola \& caser, 2014; baron \& levy, 2016). 2. positive end-expiratory airway pressure (peep) ≥ 5 cmh2o 3. oxygen saturation ≤ 93% 4. non-cardiogenic bilateral pulmonary edema on frontal chest radiograph that cannot be explained by effusion, collapsed lung or lung nodule 5. able to understand and provide voluntary informed consent

inclusion criteria: 1. male or female patients age 18 to 85, inclusive 2. confirmed positive test for covid-19 by standard reverse transcriptase polymerase chain reaction (rt-pcr) assay or equivalent 3. on mechanical ventilation (n=35), or high-flow o2 support (n=35) and: 1. disease severity level of "moderate" (pao2/fio2 of 100-200) (n=35), or "severe" (pao2/fio2 \< 100) (n=35) as established using the berlin criteria for ards (barbas, isola \& caser, 2014; baron \& levy, 2016). 2. positive end-expiratory airway pressure (peep) ≥ 5 cmh2o 3. oxygen saturation ≤ 93% 4. non-cardiogenic bilateral pulmonary edema on frontal chest radiograph that cannot be explained by effusion, collapsed lung or lung nodule 5. able to understand and provide voluntary informed consent

inclusion criteria: male or female patients age 18 to 85, inclusive confirmed positive test for covid-19 by standard reverse transcriptase polymerase chain reaction (rt-pcr) assay or equivalent on mechanical ventilation (n=35), or high-flow o2 support (n=35) and: disease severity level of "moderate" (pao2/fio2 of 100-200) (n=35), or "severe" (pao2/fio2 < 100) (n=35) as established using the berlin criteria for ards (barbas, isola & caser, 2014; baron & levy, 2016). positive end-expiratory airway pressure (peep) ≥ 5 cmh2o oxygen saturation ≤ 93% non-cardiogenic bilateral pulmonary edema on frontal chest radiograph that cannot be explained by effusion, collapsed lung or lung nodule able to understand and provide voluntary informed consent

inclusion criteria: male or female patients age 18 to 85, inclusive confirmed positive test for covid-19 by standard reverse transcriptase polymerase chain reaction (rt-pcr) assay or equivalent on mechanical ventilation (n=35), or high-flow o2 support (n=35) and: disease severity level of "moderate" (pao2/fio2 of 100-200) (n=35), or "severe" (pao2/fio2 < 100) (n=35) as established using the berlin criteria for ards (barbas, isola & caser, 2014; baron & levy, 2016). positive end-expiratory airway pressure (peep) ≥ 5 cmh2o oxygen saturation ≤ 93% non-cardiogenic bilateral pulmonary edema on frontal chest radiograph that cannot be explained by effusion, collapsed lung or lung nodule able to understand and provide voluntary informed consent

inclusion criteria: 1. male or female patients age 18 to 85, inclusive 2. confirmed positive test for covid-19 by standard reverse transcriptase polymerase chain reaction (rt-pcr) assay or equivalent 3. on mechanical ventilation (n=35), or high-flow o2 support (n=35) and: 1. disease severity level of "moderate" (pao2/fio2 of 100-200) (n=35), or "severe" (pao2/fio2 < 100) (n=35) as established using the berlin criteria for ards (barbas, isola & caser, 2014; baron & levy, 2016). 2. positive end-expiratory airway pressure (peep) ≥ 5 cmh2o 3. oxygen saturation ≤ 93% 4. non-cardiogenic bilateral pulmonary edema on frontal chest radiograph that cannot be explained by effusion, collapsed lung or lung nodule 5. able to understand and provide voluntary informed consent

inclusion criteria: 1. male or female patients age 18 to 85, inclusive 2. confirmed positive test for covid-19 by standard reverse transcriptase polymerase chain reaction (rt-pcr) assay or equivalent 3. on mechanical ventilation (n=35), or high-flow o2 support (n=35) and: 1. disease severity level of "moderate" (pao2/fio2 of 100-200) (n=35), or "severe" (pao2/fio2 < 100) (n=35) as established using the berlin criteria for ards (barbas, isola & caser, 2014; baron & levy, 2016). 2. positive end-expiratory airway pressure (peep) ≥ 5 cmh2o 3. oxygen saturation ≤ 93% 4. non-cardiogenic bilateral pulmonary edema on frontal chest radiograph that cannot be explained by effusion, collapsed lung or lung nodule 5. able to understand and provide voluntary informed consent