inclusion criteria for the phase i portion of the study: * healthy adults from 18 to \<55 and 65-\<85 years of age at the time of enrollment; * able to provide consent to participate in and having signed an informed consent form (icf); * able and willing to complete all the scheduled study procedures during the whole study follow-up period (about 6-8 months, depending on group); * negative result of hiv, hepatitis b and c screening; * oral temperature \< 38.0℃; * negative igg and igm antibodies against covid-19; * negative result of real-time quantitative pcr screening of nasopharyngeal swabs/sputum for sars-cov-2; * a body mass index (bmi) between 18-35; * hematological examination is within normal range, or no greater than a grade 1 abnormality and no clinical significance as assessed by the study investigator (including white blood cell count, lymphocyte count, neutrophil count, eosinophil count, platelet, hemoglobin, alanine aminotransferase alt, aspartate aminotransferase ast, total bilirubin, blood glucose and creatinine); * transient mild laboratory abnormalities may be rescreened once and the participant will be deemed eligible if the laboratory repeat test is normal as per local laboratory normal values and investigator assessment. * good general health status, as determined by history and physical examination no greater than 14 days prior to administration of the test article. * if female of child-bearing potential and heterosexually active, has practiced adequate contraception for 30 days prior to injection, has a negative pregnancy test on the day of injection, and has agreed to continue adequate contraception until 180 days after injection. (please refer to the glossary for the definition of child-bearing potential and adequate contraception). inclusion criteria for the phase ii portion of the study will be detailed in an amended synopsis/study protocol. exclusion criteria for the phase i portion of the study: * personal history of seizure disorder, encephalopathy or psychosis; * allergic history to any vaccine, or allergic to any ingredient of the ad5-ncov; * woman is pregnant or lactating, positive urine pregnancy test or plan to become pregnant during the next 6 months; * any acute febrile disease (oral temperature ≥38.0℃ or active infectious disease on the day of vaccination; * medical history of sars (sars-cov-1); * serious cardiovascular diseases, such as arrhythmia, conduction block, myocardial infarction, severe hypertension not controlled with medication; * serious chronic disease such as asthma, diabetes and thyroid disease, etc.; * congenital or acquired angioedema; * immunodeficiency, asplenia or functional asplenia; * platelet disorder or other bleeding disorder that may cause intramuscular injection contraindication; * immunosuppressive medication, anti-allergic, cytotoxic therapy, inhaled corticosteroids (excluding corticosteroid spray for allergic rhinitis, surface corticosteroid therapy for acute non-complicated dermatitis) in the last 6 months; * prior administration of blood products in last 4 months; * other vaccination(s) or investigational drugs within 1 month before study onset, or planned use during the study period; * prior administration of live attenuated vaccine within 1 month before study onset; * prior administration of subunit or inactivated vaccine within 14 days before study onset; * current anti-tuberculosis therapy; * any condition that in the opinion of the investigators may interfere with the participants' compliance or evaluation of study objectives or informed consent (i.e. medical, psychological, social or other conditions, etc.) exclusion criteria for the phase ii portion of the study will be detailed in an amended synopsis/study protocol.

inclusion criteria for the phase i portion of the study: * healthy adults from 18 to \<55 and 65-\<85 years of age at the time of enrollment; * able to provide consent to participate in and having signed an informed consent form (icf); * able and willing to complete all the scheduled study procedures during the whole study follow-up period (about 6-8 months, depending on group); * negative result of hiv, hepatitis b and c screening; * oral temperature \< 38.0℃; * negative igg and igm antibodies against covid-19; * negative result of real-time quantitative pcr screening of nasopharyngeal swabs/sputum for sars-cov-2; * a body mass index (bmi) between 18-35; * hematological examination is within normal range, or no greater than a grade 1 abnormality and no clinical significance as assessed by the study investigator (including white blood cell count, lymphocyte count, neutrophil count, eosinophil count, platelet, hemoglobin, alanine aminotransferase alt, aspartate aminotransferase ast, total bilirubin, blood glucose and creatinine); * transient mild laboratory abnormalities may be rescreened once and the participant will be deemed eligible if the laboratory repeat test is normal as per local laboratory normal values and investigator assessment. * good general health status, as determined by history and physical examination no greater than 14 days prior to administration of the test article. * if female of child-bearing potential and heterosexually active, has practiced adequate contraception for 30 days prior to injection, has a negative pregnancy test on the day of injection, and has agreed to continue adequate contraception until 180 days after injection. (please refer to the glossary for the definition of child-bearing potential and adequate contraception). inclusion criteria for the phase ii portion of the study will be detailed in an amended synopsis/study protocol. exclusion criteria for the phase i portion of the study: * personal history of seizure disorder, encephalopathy or psychosis; * allergic history to any vaccine, or allergic to any ingredient of the ad5-ncov; * woman is pregnant or lactating, positive urine pregnancy test or plan to become pregnant during the next 6 months; * any acute febrile disease (oral temperature ≥38.0℃ or active infectious disease on the day of vaccination; * medical history of sars (sars-cov-1); * serious cardiovascular diseases, such as arrhythmia, conduction block, myocardial infarction, severe hypertension not controlled with medication; * serious chronic disease such as asthma, diabetes and thyroid disease, etc.; * congenital or acquired angioedema; * immunodeficiency, asplenia or functional asplenia; * platelet disorder or other bleeding disorder that may cause intramuscular injection contraindication; * immunosuppressive medication, anti-allergic, cytotoxic therapy, inhaled corticosteroids (excluding corticosteroid spray for allergic rhinitis, surface corticosteroid therapy for acute non-complicated dermatitis) in the last 6 months; * prior administration of blood products in last 4 months; * other vaccination(s) or investigational drugs within 1 month before study onset, or planned use during the study period; * prior administration of live attenuated vaccine within 1 month before study onset; * prior administration of subunit or inactivated vaccine within 14 days before study onset; * current anti-tuberculosis therapy; * any condition that in the opinion of the investigators may interfere with the participants' compliance or evaluation of study objectives or informed consent (i.e. medical, psychological, social or other conditions, etc.) exclusion criteria for the phase ii portion of the study will be detailed in an amended synopsis/study protocol.

inclusion criteria for the phase i portion of the study: - healthy adults from 18 to <55 and 65-<85 years of age at the time of enrollment; - able to provide consent to participate in and having signed an informed consent form (icf); - able and willing to complete all the scheduled study procedures during the whole study follow-up period (about 6-8 months, depending on group); - negative result of hiv, hepatitis b and c screening; - oral temperature < 38.0℃; - negative igg and igm antibodies against covid-19; - negative result of real-time quantitative pcr screening of nasopharyngeal swabs/sputum for sars-cov-2; - a body mass index (bmi) between 18-35; - hematological examination is within normal range, or no greater than a grade 1 abnormality and no clinical significance as assessed by the study investigator (including white blood cell count, lymphocyte count, neutrophil count, eosinophil count, platelet, hemoglobin, alanine aminotransferase alt, aspartate aminotransferase ast, total bilirubin, blood glucose and creatinine); - transient mild laboratory abnormalities may be rescreened once and the participant will be deemed eligible if the laboratory repeat test is normal as per local laboratory normal values and investigator assessment. - good general health status, as determined by history and physical examination no greater than 14 days prior to administration of the test article. - if female of child-bearing potential and heterosexually active, has practiced adequate contraception for 30 days prior to injection, has a negative pregnancy test on the day of injection, and has agreed to continue adequate contraception until 180 days after injection. (please refer to the glossary for the definition of child-bearing potential and adequate contraception). inclusion criteria for the phase ii portion of the study will be detailed in an amended synopsis/study protocol. exclusion criteria for the phase i portion of the study: - personal history of seizure disorder, encephalopathy or psychosis; - allergic history to any vaccine, or allergic to any ingredient of the ad5-ncov; - woman is pregnant or lactating, positive urine pregnancy test or plan to become pregnant during the next 6 months; - any acute febrile disease (oral temperature ≥38.0℃ or active infectious disease on the day of vaccination; - medical history of sars (sars-cov-1); - serious cardiovascular diseases, such as arrhythmia, conduction block, myocardial infarction, severe hypertension not controlled with medication; - serious chronic disease such as asthma, diabetes and thyroid disease, etc.; - congenital or acquired angioedema; - immunodeficiency, asplenia or functional asplenia; - platelet disorder or other bleeding disorder that may cause intramuscular injection contraindication; - immunosuppressive medication, anti-allergic, cytotoxic therapy, inhaled corticosteroids (excluding corticosteroid spray for allergic rhinitis, surface corticosteroid therapy for acute non-complicated dermatitis) in the last 6 months; - prior administration of blood products in last 4 months; - other vaccination(s) or investigational drugs within 1 month before study onset, or planned use during the study period; - prior administration of live attenuated vaccine within 1 month before study onset; - prior administration of subunit or inactivated vaccine within 14 days before study onset; - current anti-tuberculosis therapy; - any condition that in the opinion of the investigators may interfere with the participants' compliance or evaluation of study objectives or informed consent (i.e. medical, psychological, social or other conditions, etc.) exclusion criteria for the phase ii portion of the study will be detailed in an amended synopsis/study protocol.

inclusion criteria for the phase i portion of the study: - healthy adults from 18 to <55 and 65-<85 years of age at the time of enrollment; - able to provide consent to participate in and having signed an informed consent form (icf); - able and willing to complete all the scheduled study procedures during the whole study follow-up period (about 6-8 months, depending on group); - negative result of hiv, hepatitis b and c screening; - oral temperature < 38.0℃; - negative igg and igm antibodies against covid-19; - negative result of real-time quantitative pcr screening of nasopharyngeal swabs/sputum for sars-cov-2; - a body mass index (bmi) between 18-35; - hematological examination is within normal range, or no greater than a grade 1 abnormality and no clinical significance as assessed by the study investigator (including white blood cell count, lymphocyte count, neutrophil count, eosinophil count, platelet, hemoglobin, alanine aminotransferase alt, aspartate aminotransferase ast, total bilirubin, blood glucose and creatinine); - transient mild laboratory abnormalities may be rescreened once and the participant will be deemed eligible if the laboratory repeat test is normal as per local laboratory normal values and investigator assessment. - good general health status, as determined by history and physical examination no greater than 14 days prior to administration of the test article. - if female of child-bearing potential and heterosexually active, has practiced adequate contraception for 30 days prior to injection, has a negative pregnancy test on the day of injection, and has agreed to continue adequate contraception until 180 days after injection. (please refer to the glossary for the definition of child-bearing potential and adequate contraception). inclusion criteria for the phase ii portion of the study will be detailed in an amended synopsis/study protocol. exclusion criteria for the phase i portion of the study: - personal history of seizure disorder, encephalopathy or psychosis; - allergic history to any vaccine, or allergic to any ingredient of the ad5-ncov; - woman is pregnant or lactating, positive urine pregnancy test or plan to become pregnant during the next 6 months; - any acute febrile disease (oral temperature ≥38.0℃ or active infectious disease on the day of vaccination; - medical history of sars (sars-cov-1); - serious cardiovascular diseases, such as arrhythmia, conduction block, myocardial infarction, severe hypertension not controlled with medication; - serious chronic disease such as asthma, diabetes and thyroid disease, etc.; - congenital or acquired angioedema; - immunodeficiency, asplenia or functional asplenia; - platelet disorder or other bleeding disorder that may cause intramuscular injection contraindication; - immunosuppressive medication, anti-allergic, cytotoxic therapy, inhaled corticosteroids (excluding corticosteroid spray for allergic rhinitis, surface corticosteroid therapy for acute non-complicated dermatitis) in the last 6 months; - prior administration of blood products in last 4 months; - other vaccination(s) or investigational drugs within 1 month before study onset, or planned use during the study period; - prior administration of live attenuated vaccine within 1 month before study onset; - prior administration of subunit or inactivated vaccine within 14 days before study onset; - current anti-tuberculosis therapy; - any condition that in the opinion of the investigators may interfere with the participants' compliance or evaluation of study objectives or informed consent (i.e. medical, psychological, social or other conditions, etc.) exclusion criteria for the phase ii portion of the study will be detailed in an amended synopsis/study protocol.