Recipient Exclusion Criteria: <br/ > <br/ >Patient/ family members who do not give consent to participate in the study. <br/ >Patients with age less than 18 years <br/ >Patients presenting with multi-organ failure <br/ >Pregnancy <br/ >Individuals with HIV and Viral Hepatitis and Cancer <br/ >Extremely moribund patients with an expected life expectancy of less than 24 hours <br/ >Hemodynamic instability requiring vasopressors <br/ >Previous history of allergy to plasma <br/ >Cirrhosis <br/ >Severe renal impairment with GFR < 30ml/min or recipients of RRT, peritoneal dialysis <br/ >Patients with uncontrolled diabetes mellitus, hypertension, arrhythmias and unstable Angina <br/ >Donors Exclusion Criteria: <br/ > <br/ >Do not fulfill all criteria of donor eligibility for donor Plasmapheresis under <br/ >the Drugs & Cosmetics Act 1940 and Rules 1945, amended 11.03.2020 <br/ >Females who have been pregnant and have not been tested for HLA antibodies or are HLA antibody positive if tested and previously transfused donors (to prevent TRALI) <br/ >Donors who have taken steroids during treatment for COVID-19

Recipient Exclusion Criteria: <br/ > <br/ >Patient/ family members who do not give consent to participate in the study. <br/ >Patients with age less than 18 years <br/ >Patients presenting with multi-organ failure <br/ >Pregnancy <br/ >Individuals with HIV and Viral Hepatitis and Cancer <br/ >Extremely moribund patients with an expected life expectancy of less than 24 hours <br/ >Hemodynamic instability requiring vasopressors <br/ >Previous history of allergy to plasma <br/ >Cirrhosis <br/ >Severe renal impairment with GFR < 30ml/min or recipients of RRT, peritoneal dialysis <br/ >Patients with uncontrolled diabetes mellitus, hypertension, arrhythmias and unstable Angina <br/ >Donors Exclusion Criteria: <br/ > <br/ >Do not fulfill all criteria of donor eligibility for donor Plasmapheresis under <br/ >the Drugs & Cosmetics Act 1940 and Rules 1945, amended 11.03.2020 <br/ >Females who have been pregnant and have not been tested for HLA antibodies or are HLA antibody positive if tested and previously transfused donors (to prevent TRALI) <br/ >Donors who have taken steroids during treatment for COVID-19

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Recipient Exclusion Criteria: <br/ > <br/ >Patient/ family members who do not give consent to participate in the study. <br/ >Patients with age less than 18 years <br/ >Patients presenting with multi-organ failure <br/ >Pregnancy <br/ >Individuals with HIV and Viral Hepatitis and Cancer <br/ >Extremely moribund patients with an expected life expectancy of less than 24 hours <br/ >Hemodynamic instability requiring vasopressors <br/ >Previous history of allergy to plasma <br/ >Cirrhosis <br/ >Severe renal impairment with GFR < 30ml/min or recipients of RRT, peritoneal dialysis <br/ >Patients with uncontrolled diabetes mellitus, hypertension, arrhythmias and unstable Angina <br/ >Donors Exclusion Criteria: <br/ > <br/ >Do not fulfill all criteria of donor eligibility for donor Plasmapheresis under <br/ >the Drugs & Cosmetics Act 1940 and Rules 1945, amended 11.03.2020 <br/ >Females who have been pregnant and have not been tested for HLA antibodies or are HLA antibody positive if tested and previously transfused donors (to prevent TRALI) <br/ >Donors who have taken steroids during treatment for COVID-19

Recipient Exclusion Criteria: <br/ > <br/ >Patient/ family members who do not give consent to participate in the study. <br/ >Patients with age less than 18 years <br/ >Patients presenting with multi-organ failure <br/ >Pregnancy <br/ >Individuals with HIV and Viral Hepatitis and Cancer <br/ >Extremely moribund patients with an expected life expectancy of less than 24 hours <br/ >Hemodynamic instability requiring vasopressors <br/ >Previous history of allergy to plasma <br/ >Cirrhosis <br/ >Severe renal impairment with GFR < 30ml/min or recipients of RRT, peritoneal dialysis <br/ >Patients with uncontrolled diabetes mellitus, hypertension, arrhythmias and unstable Angina <br/ >Donors Exclusion Criteria: <br/ > <br/ >Do not fulfill all criteria of donor eligibility for donor Plasmapheresis under <br/ >the Drugs & Cosmetics Act 1940 and Rules 1945, amended 11.03.2020 <br/ >Females who have been pregnant and have not been tested for HLA antibodies or are HLA antibody positive if tested and previously transfused donors (to prevent TRALI) <br/ >Donors who have taken steroids during treatment for COVID-19