inclusion criteria: 1. adult ≥18 years of age 2. laboratory-confirmed sars-cov-2 infection as determined by pcr or other authorized or approved assay in any specimen collected within 72 hours prior to enrollment. note - an exception must be requested to the sponsor if ≥72 hours since positive test. 3. hospitalized in participating facility. 4. documentation of pneumonia with radiographic evidence of infiltrates by imaging (e.g., chest x-ray or ct scan). 5. abnormal respiratory status that is judged worse than baseline by the investigator and as documented at any point within 24 hours prior to randomization, consistent with ordinal scale levels 5, 6 or 7, specifically defined as: * room air saturation of oxygen (sao2) \< 93%, or * requiring supplemental oxygen, or * tachypnea with respiratory rate ≥30 6. patient or proxy is willing and able to provide written informed consent and comply with all protocol requirements

inclusion criteria: 1. adult ≥18 years of age 2. laboratory-confirmed sars-cov-2 infection as determined by pcr or other authorized or approved assay in any specimen collected within 72 hours prior to enrollment. note - an exception must be requested to the sponsor if ≥72 hours since positive test. 3. hospitalized in participating facility. 4. documentation of pneumonia with radiographic evidence of infiltrates by imaging (e.g., chest x-ray or ct scan). 5. abnormal respiratory status that is judged worse than baseline by the investigator and as documented at any point within 24 hours prior to randomization, consistent with ordinal scale levels 5, 6 or 7, specifically defined as: * room air saturation of oxygen (sao2) \< 93%, or * requiring supplemental oxygen, or * tachypnea with respiratory rate ≥30 6. patient or proxy is willing and able to provide written informed consent and comply with all protocol requirements

inclusion criteria: adult ≥18 years of age laboratory-confirmed sars-cov-2 infection as determined by pcr or other authorized or approved assay in any specimen collected within 72 hours prior to enrollment. note - an exception must be requested to the sponsor if ≥72 hours since positive test. hospitalized in participating facility. documentation of pneumonia with radiographic evidence of infiltrates by imaging (e.g., chest x-ray or ct scan). abnormal respiratory status that is judged worse than baseline by the investigator and as documented at any point within 24 hours prior to randomization, consistent with ordinal scale levels 5, 6 or 7, specifically defined as: room air saturation of oxygen (sao2) < 93%, or requiring supplemental oxygen, or tachypnea with respiratory rate ≥30 patient or proxy is willing and able to provide written informed consent and comply with all protocol requirements

inclusion criteria: adult ≥18 years of age laboratory-confirmed sars-cov-2 infection as determined by pcr or other authorized or approved assay in any specimen collected within 72 hours prior to enrollment. note - an exception must be requested to the sponsor if ≥72 hours since positive test. hospitalized in participating facility. documentation of pneumonia with radiographic evidence of infiltrates by imaging (e.g., chest x-ray or ct scan). abnormal respiratory status that is judged worse than baseline by the investigator and as documented at any point within 24 hours prior to randomization, consistent with ordinal scale levels 5, 6 or 7, specifically defined as: room air saturation of oxygen (sao2) < 93%, or requiring supplemental oxygen, or tachypnea with respiratory rate ≥30 patient or proxy is willing and able to provide written informed consent and comply with all protocol requirements

inclusion criteria: 1. adult ≥18 years of age 2. laboratory-confirmed sars-cov-2 infection as determined by pcr or other authorized or approved assay in any specimen collected within 72 hours prior to enrollment. note - an exception must be requested to the sponsor if ≥72 hours since positive test. 3. hospitalized in participating facility. 4. documentation of pneumonia with radiographic evidence of infiltrates by imaging (e.g., chest x-ray or ct scan). 5. abnormal respiratory status that is judged worse than baseline by the investigator and as documented at any point within 24 hours prior to randomization, consistent with ordinal scale levels 5, 6 or 7, specifically defined as: - room air saturation of oxygen (sao2) < 93%, or - requiring supplemental oxygen, or - tachypnea with respiratory rate ≥30 6. patient or proxy is willing and able to provide written informed consent and comply with all protocol requirements

inclusion criteria: 1. adult ≥18 years of age 2. laboratory-confirmed sars-cov-2 infection as determined by pcr or other authorized or approved assay in any specimen collected within 72 hours prior to enrollment. note - an exception must be requested to the sponsor if ≥72 hours since positive test. 3. hospitalized in participating facility. 4. documentation of pneumonia with radiographic evidence of infiltrates by imaging (e.g., chest x-ray or ct scan). 5. abnormal respiratory status that is judged worse than baseline by the investigator and as documented at any point within 24 hours prior to randomization, consistent with ordinal scale levels 5, 6 or 7, specifically defined as: - room air saturation of oxygen (sao2) < 93%, or - requiring supplemental oxygen, or - tachypnea with respiratory rate ≥30 6. patient or proxy is willing and able to provide written informed consent and comply with all protocol requirements