inclusion criteria: 1. signed informed consent (subject; legally authorized representative) or signed conclusion of panel of independent medical doctors 2. males and non-pregnant females aged 18 years or older at the ic date 3. positive test for sars-cov2 nucleic acid (rna) at the ic date 4. admitted as inpatient to a hospital with radiologically confirmed pneumonia 5. severe form of covid-19. 6. subjects meeting any of the following criteria: * total respiratory rate \> 30 breaths per minute * spo2 ≤ 93% * pao2 /fio2 ≤ 300 mmhg * chest imaging (x-ray, ct, us) showed lesion progression within 24-48 hours \>50% * decrease of consciousness level, psychomotor agitation/irritability * hemodynamically unstable (systolic blood pressure \<90 mmhg or diastolic blood pressure \< 60 mmhg or urine output \< 20 ml/h) * arterial lactate \> 2 mmol/l * qsofa (quick sequential organ failure assessment score) \> 2. subjects meeting three following criteria: low blood pressure (sbp ≤ 100 mmhg); high respiratory rate (≥ 22 breaths/min); altered mentation (glasgow coma scale ≤ 14)

inclusion criteria: 1. signed informed consent (subject; legally authorized representative) or signed conclusion of panel of independent medical doctors 2. males and non-pregnant females aged 18 years or older at the ic date 3. positive test for sars-cov2 nucleic acid (rna) at the ic date 4. admitted as inpatient to a hospital with radiologically confirmed pneumonia 5. severe form of covid-19. 6. subjects meeting any of the following criteria: * total respiratory rate \> 30 breaths per minute * spo2 ≤ 93% * pao2 /fio2 ≤ 300 mmhg * chest imaging (x-ray, ct, us) showed lesion progression within 24-48 hours \>50% * decrease of consciousness level, psychomotor agitation/irritability * hemodynamically unstable (systolic blood pressure \<90 mmhg or diastolic blood pressure \< 60 mmhg or urine output \< 20 ml/h) * arterial lactate \> 2 mmol/l * qsofa (quick sequential organ failure assessment score) \> 2. subjects meeting three following criteria: low blood pressure (sbp ≤ 100 mmhg); high respiratory rate (≥ 22 breaths/min); altered mentation (glasgow coma scale ≤ 14)

inclusion criteria: signed informed consent (subject; legally authorized representative) or signed conclusion of panel of independent medical doctors males and non-pregnant females aged 18 years or older at the ic date positive test for sars-cov2 nucleic acid (rna) at the ic date admitted as inpatient to a hospital with radiologically confirmed pneumonia severe form of covid-19. subjects meeting any of the following criteria: total respiratory rate > 30 breaths per minute spo2 ≤ 93% pao2 /fio2 ≤ 300 mmhg chest imaging (x-ray, ct, us) showed lesion progression within 24-48 hours >50% decrease of consciousness level, psychomotor agitation/irritability hemodynamically unstable (systolic blood pressure <90 mmhg or diastolic blood pressure < 60 mmhg or urine output < 20 ml/h) arterial lactate > 2 mmol/l qsofa (quick sequential organ failure assessment score) > 2. subjects meeting three following criteria: low blood pressure (sbp ≤ 100 mmhg); high respiratory rate (≥ 22 breaths/min); altered mentation (glasgow coma scale ≤ 14)

inclusion criteria: signed informed consent (subject; legally authorized representative) or signed conclusion of panel of independent medical doctors males and non-pregnant females aged 18 years or older at the ic date positive test for sars-cov2 nucleic acid (rna) at the ic date admitted as inpatient to a hospital with radiologically confirmed pneumonia severe form of covid-19. subjects meeting any of the following criteria: total respiratory rate > 30 breaths per minute spo2 ≤ 93% pao2 /fio2 ≤ 300 mmhg chest imaging (x-ray, ct, us) showed lesion progression within 24-48 hours >50% decrease of consciousness level, psychomotor agitation/irritability hemodynamically unstable (systolic blood pressure <90 mmhg or diastolic blood pressure < 60 mmhg or urine output < 20 ml/h) arterial lactate > 2 mmol/l qsofa (quick sequential organ failure assessment score) > 2. subjects meeting three following criteria: low blood pressure (sbp ≤ 100 mmhg); high respiratory rate (≥ 22 breaths/min); altered mentation (glasgow coma scale ≤ 14)

inclusion criteria: 1. signed informed consent (subject; legally authorized representative) or signed conclusion of panel of independent medical doctors 2. males and non-pregnant females aged 18 years or older at the ic date 3. positive test for sars-cov2 nucleic acid (rna) at the ic date 4. admitted as inpatient to a hospital with radiologically confirmed pneumonia 5. severe form of covid-19. 6. subjects meeting any of the following criteria: - total respiratory rate > 30 breaths per minute - spo2 ≤ 93% - pao2 /fio2 ≤ 300 mmhg - chest imaging (x-ray, ct, us) showed lesion progression within 24-48 hours >50% - decrease of consciousness level, psychomotor agitation/irritability - hemodynamically unstable (systolic blood pressure <90 mmhg or diastolic blood pressure < 60 mmhg or urine output < 20 ml/h) - arterial lactate > 2 mmol/l - qsofa (quick sequential organ failure assessment score) > 2. subjects meeting three following criteria: low blood pressure (sbp ≤ 100 mmhg); high respiratory rate (≥ 22 breaths/min); altered mentation (glasgow coma scale ≤ 14)

inclusion criteria: 1. signed informed consent (subject; legally authorized representative) or signed conclusion of panel of independent medical doctors 2. males and non-pregnant females aged 18 years or older at the ic date 3. positive test for sars-cov2 nucleic acid (rna) at the ic date 4. admitted as inpatient to a hospital with radiologically confirmed pneumonia 5. severe form of covid-19. 6. subjects meeting any of the following criteria: - total respiratory rate > 30 breaths per minute - spo2 ≤ 93% - pao2 /fio2 ≤ 300 mmhg - chest imaging (x-ray, ct, us) showed lesion progression within 24-48 hours >50% - decrease of consciousness level, psychomotor agitation/irritability - hemodynamically unstable (systolic blood pressure <90 mmhg or diastolic blood pressure < 60 mmhg or urine output < 20 ml/h) - arterial lactate > 2 mmol/l - qsofa (quick sequential organ failure assessment score) > 2. subjects meeting three following criteria: low blood pressure (sbp ≤ 100 mmhg); high respiratory rate (≥ 22 breaths/min); altered mentation (glasgow coma scale ≤ 14)