inclusion criteria: * adults (≥ 18 years of age) * signed informed consent by any patient capable of giving consent, or, when the patient is not capable of giving consent, by his or her legal/authorized representative or according to local guidelines * patients clinically diagnosed with sars-cov-2 virus by pcr or by other approved diagnostic methodology * hospitalized with covid-19-induced pneumonia evidenced by chest x-ray or ct scan with pulmonary infiltrates * patient requiring oxygen supplementation (i.e. with a spo2 ≤ 92% while breathing room air) and having a pao2/fio2 ratio ≤ 300 mmhg * lactate dehydrogenase (ldh) \> normal range and at least one of the following: 1. fever \> 38.0 °c; 2. increased levels of c-reactive protein (crp) ≥ 10x unl mg/l (≥ 60 mg/l); 3. increased levels of ferritin ≥ 2.5x unl ( ≥ 1000 μg/l)

inclusion criteria: * adults (≥ 18 years of age) * signed informed consent by any patient capable of giving consent, or, when the patient is not capable of giving consent, by his or her legal/authorized representative or according to local guidelines * patients clinically diagnosed with sars-cov-2 virus by pcr or by other approved diagnostic methodology * hospitalized with covid-19-induced pneumonia evidenced by chest x-ray or ct scan with pulmonary infiltrates * patient requiring oxygen supplementation (i.e. with a spo2 ≤ 92% while breathing room air) and having a pao2/fio2 ratio ≤ 300 mmhg * lactate dehydrogenase (ldh) \> normal range and at least one of the following: 1. fever \> 38.0 °c; 2. increased levels of c-reactive protein (crp) ≥ 10x unl mg/l (≥ 60 mg/l); 3. increased levels of ferritin ≥ 2.5x unl ( ≥ 1000 μg/l)

inclusion criteria: adults (≥ 18 years of age) signed informed consent by any patient capable of giving consent, or, when the patient is not capable of giving consent, by his or her legal/authorized representative or according to local guidelines patients clinically diagnosed with sars-cov-2 virus by pcr or by other approved diagnostic methodology hospitalized with covid-19-induced pneumonia evidenced by chest x-ray or ct scan with pulmonary infiltrates patient requiring oxygen supplementation (i.e. with a spo2 ≤ 92% while breathing room air) and having a pao2/fio2 ratio ≤ 300 mmhg lactate dehydrogenase (ldh) > normal range and at least one of the following: fever > 38.0 °c; increased levels of c-reactive protein (crp) ≥ 10x unl mg/l (≥ 60 mg/l); increased levels of ferritin ≥ 2.5x unl ( ≥ 1000 μg/l)

inclusion criteria: adults (≥ 18 years of age) signed informed consent by any patient capable of giving consent, or, when the patient is not capable of giving consent, by his or her legal/authorized representative or according to local guidelines patients clinically diagnosed with sars-cov-2 virus by pcr or by other approved diagnostic methodology hospitalized with covid-19-induced pneumonia evidenced by chest x-ray or ct scan with pulmonary infiltrates patient requiring oxygen supplementation (i.e. with a spo2 ≤ 92% while breathing room air) and having a pao2/fio2 ratio ≤ 300 mmhg lactate dehydrogenase (ldh) > normal range and at least one of the following: fever > 38.0 °c; increased levels of c-reactive protein (crp) ≥ 10x unl mg/l (≥ 60 mg/l); increased levels of ferritin ≥ 2.5x unl ( ≥ 1000 μg/l)

inclusion criteria: - adults (≥ 18 years of age) - signed informed consent by any patient capable of giving consent, or, when the patient is not capable of giving consent, by his or her legal/authorized representative or according to local guidelines - patients clinically diagnosed with sars-cov-2 virus by pcr or by other approved diagnostic methodology - hospitalized with covid-19-induced pneumonia evidenced by chest x-ray or ct scan with pulmonary infiltrates - patient requiring oxygen supplementation (i.e. with a spo2 ≤ 92% while breathing room air) and having a pao2/fio2 ratio ≤ 300 mmhg - lactate dehydrogenase (ldh) > normal range and at least one of the following: 1. fever > 38.0 °c; 2. increased levels of c-reactive protein (crp) ≥ 10x unl mg/l (≥ 60 mg/l); 3. increased levels of ferritin ≥ 2.5x unl ( ≥ 1000 μg/l)

inclusion criteria: - adults (≥ 18 years of age) - signed informed consent by any patient capable of giving consent, or, when the patient is not capable of giving consent, by his or her legal/authorized representative or according to local guidelines - patients clinically diagnosed with sars-cov-2 virus by pcr or by other approved diagnostic methodology - hospitalized with covid-19-induced pneumonia evidenced by chest x-ray or ct scan with pulmonary infiltrates - patient requiring oxygen supplementation (i.e. with a spo2 ≤ 92% while breathing room air) and having a pao2/fio2 ratio ≤ 300 mmhg - lactate dehydrogenase (ldh) > normal range and at least one of the following: 1. fever > 38.0 °c; 2. increased levels of c-reactive protein (crp) ≥ 10x unl mg/l (≥ 60 mg/l); 3. increased levels of ferritin ≥ 2.5x unl ( ≥ 1000 μg/l)