1. To evaluate the efficacy of Mw by measuring the improvement in Ordinal scale. <br/ > <br/ >2. To evaluate 28-day mortality.Timepoint: 1. From baseline to day 3; 7; 14; 21 and 28 and day of transfer from ICU; if earlier than 28 days. <br/ > <br/ >2.Till day 28; post-randomization or death or discharge; whichever is earlier.

1. To evaluate the efficacy of Mw by measuring the improvement in Ordinal scale. <br/ > <br/ >2. To evaluate 28-day mortality.Timepoint: 1. From baseline to day 3; 7; 14; 21 and 28 and day of transfer from ICU; if earlier than 28 days. <br/ > <br/ >2.Till day 28; post-randomization or death or discharge; whichever is earlier.

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1. To evaluate the efficacy of Mw by measuring the improvement in Ordinal scale. <br/ > <br/ >2. To evaluate 28-day mortality.Timepoint: 1. From baseline to day 3; 7; 14; 21 and 28 and day of transfer from ICU; if earlier than 28 days. <br/ > <br/ >2.Till day 28; post-randomization or death or discharge; whichever is earlier.

1. To evaluate the efficacy of Mw by measuring the improvement in Ordinal scale. <br/ > <br/ >2. To evaluate 28-day mortality.Timepoint: 1. From baseline to day 3; 7; 14; 21 and 28 and day of transfer from ICU; if earlier than 28 days. <br/ > <br/ >2.Till day 28; post-randomization or death or discharge; whichever is earlier.

To evaluate the efficacy of Mw by measuring the improvement in organ dysfunction (or occurrence of new organ dysfunction) based on Change in Sequential Organ Failure Assessment (SOFA) score and Ordinal scale.Timepoint: From baseline to day 3; 7; 14; 21 and 28 and day of transfer from ICU; if earlier than 28 days.

To evaluate the efficacy of Mw by measuring the improvement in organ dysfunction (or occurrence of new organ dysfunction) based on Change in Sequential Organ Failure Assessment (SOFA) score and Ordinal scale.Timepoint: From baseline to day 3; 7; 14; 21 and 28 and day of transfer from ICU; if earlier than 28 days.