Recipient: <br/ >Severe COVID -19 infections defined as WHO Interim Guidance and the Guideline of Diagnosis and Treatment of COVID-19 of National Health Commission of China (version 5.0) with confirmation by real-time RT-PCR assay with severe disease i.e. meeting any 2 of the following criteria- <br/ >1. Respiratory distress, RR â?¥30 beats/min <br/ >2. Oxygen saturation level less than 93% in resting state <br/ >3. Partial pressure of oxygen (PaO2)/oxygen concentration (FiO2) â?¤ 300 mmHg. <br/ >4. Lung infiltrates > 50% within 24 to 48 hours <br/ >5. Very sick (on ventilator) and patients with co-morbidities such as patients with known co- <br/ > morbid diseases (COPD, CAD, CLD, CKD, cardiopulmonary disease-structural or valvular heart <br/ > disease) <br/ >6. Patient presenting with multi organ failure or requiring mechanical ventilation. <br/ >7. Minimum age: 18 yrs to maximum age- no limit as per recent protocol amendment. <br/ > <br/ >Donor: <br/ >â?¢ Known case of recovered COVID-19 Infection, and <br/ >â?¢ Complete resolution of symptoms at least 28 days prior to donation or <br/ >Complete resolution of symptoms at least 14 days prior to donation and negative results for COVID-19 either from one or more nasopharyngeal swab specimens or by a molecular diagnostic test from the blood, <br/ > And <br/ >Negative RT-PCR for COVID-19 on two sequential paired nasopharyngeal and throat specimens > 24 hrs apart (WHO-CDC guideline). <br/ >â?¢ Donor Plasma after 2 negative tests and 2 weeks of remaining asymptomatic, without antibody titre & presence of IgG/IgM antibodies to COVID-19 by serological as per manufacturers instructions. Donors negative for these will be deferred). <br/ >â?¢ Fulfill all criteria of donor eligibility for donor Plasmapheresis under the Drugs & Cosmetics Act and Rules 1945, amended 11.03.2020.

Recipient: <br/ >Severe COVID -19 infections defined as WHO Interim Guidance and the Guideline of Diagnosis and Treatment of COVID-19 of National Health Commission of China (version 5.0) with confirmation by real-time RT-PCR assay with severe disease i.e. meeting any 2 of the following criteria- <br/ >1. Respiratory distress, RR â?¥30 beats/min <br/ >2. Oxygen saturation level less than 93% in resting state <br/ >3. Partial pressure of oxygen (PaO2)/oxygen concentration (FiO2) â?¤ 300 mmHg. <br/ >4. Lung infiltrates > 50% within 24 to 48 hours <br/ >5. Very sick (on ventilator) and patients with co-morbidities such as patients with known co- <br/ > morbid diseases (COPD, CAD, CLD, CKD, cardiopulmonary disease-structural or valvular heart <br/ > disease) <br/ >6. Patient presenting with multi organ failure or requiring mechanical ventilation. <br/ >7. Minimum age: 18 yrs to maximum age- no limit as per recent protocol amendment. <br/ > <br/ >Donor: <br/ >â?¢ Known case of recovered COVID-19 Infection, and <br/ >â?¢ Complete resolution of symptoms at least 28 days prior to donation or <br/ >Complete resolution of symptoms at least 14 days prior to donation and negative results for COVID-19 either from one or more nasopharyngeal swab specimens or by a molecular diagnostic test from the blood, <br/ > And <br/ >Negative RT-PCR for COVID-19 on two sequential paired nasopharyngeal and throat specimens > 24 hrs apart (WHO-CDC guideline). <br/ >â?¢ Donor Plasma after 2 negative tests and 2 weeks of remaining asymptomatic, without antibody titre & presence of IgG/IgM antibodies to COVID-19 by serological as per manufacturers instructions. Donors negative for these will be deferred). <br/ >â?¢ Fulfill all criteria of donor eligibility for donor Plasmapheresis under the Drugs & Cosmetics Act and Rules 1945, amended 11.03.2020.

Recipient: <br/ >Severe COVID -19 infections defined as WHO Interim Guidance and the Guideline of Diagnosis and Treatment of COVID-19 of National Health Commission of China (version 5.0) with confirmation by real-time RT-PCR assay with severe disease i.e. meeting any 2 of the following criteria- <br/ >1. Respiratory distress, RR â?¥30 beats/min <br/ >2. Oxygen saturation level less than 93% in resting state <br/ >3. Partial pressure of oxygen (PaO2)/oxygen concentration (FiO2) â?¤ 300 mmHg. <br/ >4. Lung infiltrates > 50% within 24 to 48 hours <br/ >5. Very sick (on ventilator) and patients with co-morbidities such as patients with known co- <br/ > morbid diseases (COPD, CAD, CLD, CKD, cardiopulmonary disease-structural or valvular heart <br/ > disease) <br/ >6. Patient presenting with multi organ failure or requiring mechanical ventilation. <br/ >7. Minimum age: 18 yrs to maximum age- no limit as per recent protocol amendment. <br/ > <br/ >Donor: <br/ >â?¢ Known case of recovered COVID-19 Infection, and <br/ >â?¢ Complete resolution of symptoms at least 28 days prior to donation or <br/ >Complete resolution of symptoms at least 14 days prior to donation and negative results for COVID-19 either from one or more nasopharyngeal swab specimens or by a molecular diagnostic test from the blood, <br/ > And <br/ >Negative RT-PCR for COVID-19 on two sequential paired nasopharyngeal and throat specimens > 24 hrs apart (WHO-CDC guideline). <br/ >â?¢ Donor Plasma after 2 negative tests and 2 weeks of remaining asymptomatic, without antibody titre & presence of IgG/IgM antibodies to COVID-19 by serological as per manufacturers instructions. Donors negative for these will be deferred). <br/ >â?¢ Fulfill all criteria of donor eligibility for donor Plasmapheresis under the Drugs & Cosmetics Act and Rules 1945, amended 11.03.2020.

Recipient: <br/ >Severe COVID -19 infections defined as WHO Interim Guidance and the Guideline of Diagnosis and Treatment of COVID-19 of National Health Commission of China (version 5.0) with confirmation by real-time RT-PCR assay with severe disease i.e. meeting any 2 of the following criteria- <br/ >1. Respiratory distress, RR â?¥30 beats/min <br/ >2. Oxygen saturation level less than 93% in resting state <br/ >3. Partial pressure of oxygen (PaO2)/oxygen concentration (FiO2) â?¤ 300 mmHg. <br/ >4. Lung infiltrates > 50% within 24 to 48 hours <br/ >5. Very sick (on ventilator) and patients with co-morbidities such as patients with known co- <br/ > morbid diseases (COPD, CAD, CLD, CKD, cardiopulmonary disease-structural or valvular heart <br/ > disease) <br/ >6. Patient presenting with multi organ failure or requiring mechanical ventilation. <br/ >7. Minimum age: 18 yrs to maximum age- no limit as per recent protocol amendment. <br/ > <br/ >Donor: <br/ >â?¢ Known case of recovered COVID-19 Infection, and <br/ >â?¢ Complete resolution of symptoms at least 28 days prior to donation or <br/ >Complete resolution of symptoms at least 14 days prior to donation and negative results for COVID-19 either from one or more nasopharyngeal swab specimens or by a molecular diagnostic test from the blood, <br/ > And <br/ >Negative RT-PCR for COVID-19 on two sequential paired nasopharyngeal and throat specimens > 24 hrs apart (WHO-CDC guideline). <br/ >â?¢ Donor Plasma after 2 negative tests and 2 weeks of remaining asymptomatic, without antibody titre & presence of IgG/IgM antibodies to COVID-19 by serological as per manufacturers instructions. Donors negative for these will be deferred). <br/ >â?¢ Fulfill all criteria of donor eligibility for donor Plasmapheresis under the Drugs & Cosmetics Act and Rules 1945, amended 11.03.2020.