* intubated patients * demonstrated or suspected uncontrolled systemic severe infection, such as sepsis (e.g.: positive blood culture, or procalcitonin ≥0.25 µg/l) * demonstrated local extrapulmonary abscess * ards due to cardiac failure or fluid overload * concomitant treatment with immunomodulatory /immunosuppressive drugs , which have potential activity against the disease * multi organ failure (mof) * severe renal failure (ckd, by defition glomerular filtration rate \<30 ml/min) * neisseria meningitidis infection that is not resolved * current treatment with a complement inhibitor * intravenous immunoglobulin (ivig) within 3 weeks prior to screening * participation in another interventional treatment study within 30 days before initiation of the study treatment (day 1 in this study) or within 5 half-lives of that investigational product, whichever is greater. * chemotherapy for less than 3months * pregnancy * age \<18.

* intubated patients * demonstrated or suspected uncontrolled systemic severe infection, such as sepsis (e.g.: positive blood culture, or procalcitonin ≥0.25 µg/l) * demonstrated local extrapulmonary abscess * ards due to cardiac failure or fluid overload * concomitant treatment with immunomodulatory /immunosuppressive drugs , which have potential activity against the disease * multi organ failure (mof) * severe renal failure (ckd, by defition glomerular filtration rate \<30 ml/min) * neisseria meningitidis infection that is not resolved * current treatment with a complement inhibitor * intravenous immunoglobulin (ivig) within 3 weeks prior to screening * participation in another interventional treatment study within 30 days before initiation of the study treatment (day 1 in this study) or within 5 half-lives of that investigational product, whichever is greater. * chemotherapy for less than 3months * pregnancy * age \<18.

- intubated patients - demonstrated or suspected uncontrolled systemic severe infection, such as sepsis (e.g.: positive blood culture, or procalcitonin ≥0.25 µg/l) - demonstrated local extrapulmonary abscess - ards due to cardiac failure or fluid overload - concomitant treatment with immunomodulatory /immunosuppressive drugs , which have potential activity against the disease - multi organ failure (mof) - severe renal failure (ckd, by defition glomerular filtration rate <30 ml/min) - neisseria meningitidis infection that is not resolved - current treatment with a complement inhibitor - intravenous immunoglobulin (ivig) within 3 weeks prior to screening - participation in another interventional treatment study within 30 days before initiation of the study treatment (day 1 in this study) or within 5 half-lives of that investigational product, whichever is greater. - chemotherapy for less than 3months - pregnancy - age <18.

- intubated patients - demonstrated or suspected uncontrolled systemic severe infection, such as sepsis (e.g.: positive blood culture, or procalcitonin ≥0.25 µg/l) - demonstrated local extrapulmonary abscess - ards due to cardiac failure or fluid overload - concomitant treatment with immunomodulatory /immunosuppressive drugs , which have potential activity against the disease - multi organ failure (mof) - severe renal failure (ckd, by defition glomerular filtration rate <30 ml/min) - neisseria meningitidis infection that is not resolved - current treatment with a complement inhibitor - intravenous immunoglobulin (ivig) within 3 weeks prior to screening - participation in another interventional treatment study within 30 days before initiation of the study treatment (day 1 in this study) or within 5 half-lives of that investigational product, whichever is greater. - chemotherapy for less than 3months - pregnancy - age <18.