1. Patients with end stage heart failure, 2. Recent cardiac intervention (less than 2 months): coronary angioplasty, ICD, CABG, Valvuloplasty or replacement, 3. Pulmonary fibrosis or advanced COPD, 4. End stage kidney or liver disease, 5. Pregnant or lactating ladies, 6. Patients on immunosuppressive therapy, 7. Active tuberculosis, 8. Active hepatitis, 9. Patients requiring planned blood transfusion (Thalasemia major, aplastic anemia).

1. Patients with end stage heart failure, 2. Recent cardiac intervention (less than 2 months): coronary angioplasty, ICD, CABG, Valvuloplasty or replacement, 3. Pulmonary fibrosis or advanced COPD, 4. End stage kidney or liver disease, 5. Pregnant or lactating ladies, 6. Patients on immunosuppressive therapy, 7. Active tuberculosis, 8. Active hepatitis, 9. Patients requiring planned blood transfusion (Thalasemia major, aplastic anemia).