1) Patients with specific contraindications of ulinastatin, 2) Female subjects had a positive urine pregnancy test or were lactating during the screening period, 3) Patients who are using Civerex and Gabexate, 4) Factors that may increase the mortality rate, which patients with severe other basic diseases such as tumor, severe malnutrition, etc., 5) The participants who were considered by the researchers were not suitable to participate in the clinical trial.

1) Patients with specific contraindications of ulinastatin, 2) Female subjects had a positive urine pregnancy test or were lactating during the screening period, 3) Patients who are using Civerex and Gabexate, 4) Factors that may increase the mortality rate, which patients with severe other basic diseases such as tumor, severe malnutrition, etc., 5) The participants who were considered by the researchers were not suitable to participate in the clinical trial.