1. Cases of severe vomiting or difficulty in ingesting medication, 2. Pregnant and lactating women, 3. Lopinavir/ridonavir, ribavirin, interferon and monoclonal antibody were received 3 days before enrollment, 4. Cases of respiratory failure requiring mechanical ventilation, 5. Cases of shock, 6. Complications of other organ failure require ICU care, 7. Patients were clinically predicted with no hope of survival and only received hospice care, or those who were in a deep coma and did not respond to supportive treatment measures within three hours of admission.

1. Cases of severe vomiting or difficulty in ingesting medication, 2. Pregnant and lactating women, 3. Lopinavir/ridonavir, ribavirin, interferon and monoclonal antibody were received 3 days before enrollment, 4. Cases of respiratory failure requiring mechanical ventilation, 5. Cases of shock, 6. Complications of other organ failure require ICU care, 7. Patients were clinically predicted with no hope of survival and only received hospice care, or those who were in a deep coma and did not respond to supportive treatment measures within three hours of admission.