(1) Female patients who are pregnant or planning to become pregnant within 7 months, (2) ALT is higher than 10 times the upper limit of normal value, or total bilirubin is highter than 2 times the upper limit of normal value, or the stage of decompensation of cirrhosis, or has had decompensation of cirrhosis, (3) The number of peripheral blood leukocytes and/or platelets is lower than the lower limit of normal value, (4) There are serious important organs such as cardiovascular,lung,kidney,brain lesions and fundus lesions, (5) Combined with autoimmune disease,mental illness,diabetes,and abnormal thyroid function (hyperthyroidism or hypothyroidism), (6) Those diagnosed or suspected of malignant tumors, (7) Those who are using immunosuppressive drugs or after organ transplantation or who are preparing to undergo organ transplantation, (8) Drug addicts or people with HIV infection, (9) Those who are allergic to interferon, (10) There are other situations in which interferon is not suitable for use by the doctor in charge, (11) Men who did not take effective contraception during and after the treatment period.

(1) Female patients who are pregnant or planning to become pregnant within 7 months, (2) ALT is higher than 10 times the upper limit of normal value, or total bilirubin is highter than 2 times the upper limit of normal value, or the stage of decompensation of cirrhosis, or has had decompensation of cirrhosis, (3) The number of peripheral blood leukocytes and/or platelets is lower than the lower limit of normal value, (4) There are serious important organs such as cardiovascular,lung,kidney,brain lesions and fundus lesions, (5) Combined with autoimmune disease,mental illness,diabetes,and abnormal thyroid function (hyperthyroidism or hypothyroidism), (6) Those diagnosed or suspected of malignant tumors, (7) Those who are using immunosuppressive drugs or after organ transplantation or who are preparing to undergo organ transplantation, (8) Drug addicts or people with HIV infection, (9) Those who are allergic to interferon, (10) There are other situations in which interferon is not suitable for use by the doctor in charge, (11) Men who did not take effective contraception during and after the treatment period.