1. Family history of seizure, epilepsy, brain or mental disease, 2. Subject allergic to any component of the investigational vaccine, or a more severe allergic reaction and history of allergies in the past, 3. Woman who is pregnant, breast-feeding or positive in ß-HCG (human chorionic gonadotropin) pregnancy test (urine) on day of enrollment, or become pregnant during the next 6 months, 4. Any acute fever disease or infections, 5. History of SARS, 6. Major congenital defects or not well-controlled chronic illness, such as asthma, diabetes, or thyroid disease, 7. Serious cardiovascular diseases, such as arrhythmia, conduction block, myocardial infarction, severe hypertension without controllable drugs, etc., 8. Hereditary angioneurotic edema or acquired angioneurotic edema, 9. Urticaria in last one year, 10. No spleen or functional spleen, 11. Platelet disorder or other bleeding disorder may cause injection contraindication, 12. Faint at the sight of needles, 13. Prior administration of immunodepressant or corticosteroids,antianaphylaxis treatment, cytotoxic treatment in last 6 months, 14. Prior administration of blood products in last 4 months, 15. Prior administration of other research medicines in last 1 month, 16. Prior administration of attenuated vaccine in last 1 month, 17. Prior administration of inactivated vaccine in last 14 days, 18. Current anti-tuberculosis prophylaxis or therapy, 19. According to the judgement of investigator,various medical, psychological,social or other conditions, those could affect the subjects to sign informed consent.

1. Family history of seizure, epilepsy, brain or mental disease, 2. Subject allergic to any component of the investigational vaccine, or a more severe allergic reaction and history of allergies in the past, 3. Woman who is pregnant, breast-feeding or positive in ß-HCG (human chorionic gonadotropin) pregnancy test (urine) on day of enrollment, or become pregnant during the next 6 months, 4. Any acute fever disease or infections, 5. History of SARS, 6. Major congenital defects or not well-controlled chronic illness, such as asthma, diabetes, or thyroid disease, 7. Serious cardiovascular diseases, such as arrhythmia, conduction block, myocardial infarction, severe hypertension without controllable drugs, etc., 8. Hereditary angioneurotic edema or acquired angioneurotic edema, 9. Urticaria in last one year, 10. No spleen or functional spleen, 11. Platelet disorder or other bleeding disorder may cause injection contraindication, 12. Faint at the sight of needles, 13. Prior administration of immunodepressant or corticosteroids,antianaphylaxis treatment, cytotoxic treatment in last 6 months, 14. Prior administration of blood products in last 4 months, 15. Prior administration of other research medicines in last 1 month, 16. Prior administration of attenuated vaccine in last 1 month, 17. Prior administration of inactivated vaccine in last 14 days, 18. Current anti-tuberculosis prophylaxis or therapy, 19. According to the judgement of investigator,various medical, psychological,social or other conditions, those could affect the subjects to sign informed consent.