inclusion criteria: 1. adult (≥ 18 years old) men or women, hospitalized or not hospitalized, diagnosed for sars-cov-2 infection by pcr, with at least one associated risk factor. considered risk factors are: * age ≥ 65 years * obesity defined as bmi ≥ 30 * recent history of uncontrolled high blood pressure (sbp \> 150 mm hg dbp \>100 mm hg) according to investigator * treated diabetes (type i or ii) * history of ischemic cardiovascular disease 2. symptomatic patients at enrollment. symptoms are defined as fever (body temperature ≥ 37.8 c oral/tympanic, or ≥ 38.2 c rectal) for more than 24 hours associated either with headache, sore throat, dry cough, fatigue, chest pain or choking sensation (with no associated respiratory distress), myalgia, anosmia or ageusia. 3. patients with pulse oximetry arterial saturation ≥ 92 % on room air at enrolment. 4. patients with the following hematological and biochemical laboratory parameters obtained within 7 days prior to day 0: * hemoglobin above 9.0 g / dl * absolute neutrophil count ≥ 1000 / mm3 * platelets ≥ 100 000 mm3; * creatinine clearance ≥ 50 ml / min by the cockcroft gault formula * total serum bilirubin \< 2 x uln * alkaline phosphatase \< 2 x uln, ast (sgot) and alt (sgpt) \< 3 x uln;

inclusion criteria: 1. adult (≥ 18 years old) men or women, hospitalized or not hospitalized, diagnosed for sars-cov-2 infection by pcr, with at least one associated risk factor. considered risk factors are: * age ≥ 65 years * obesity defined as bmi ≥ 30 * recent history of uncontrolled high blood pressure (sbp \> 150 mm hg dbp \>100 mm hg) according to investigator * treated diabetes (type i or ii) * history of ischemic cardiovascular disease 2. symptomatic patients at enrollment. symptoms are defined as fever (body temperature ≥ 37.8 c oral/tympanic, or ≥ 38.2 c rectal) for more than 24 hours associated either with headache, sore throat, dry cough, fatigue, chest pain or choking sensation (with no associated respiratory distress), myalgia, anosmia or ageusia. 3. patients with pulse oximetry arterial saturation ≥ 92 % on room air at enrolment. 4. patients with the following hematological and biochemical laboratory parameters obtained within 7 days prior to day 0: * hemoglobin above 9.0 g / dl * absolute neutrophil count ≥ 1000 / mm3 * platelets ≥ 100 000 mm3; * creatinine clearance ≥ 50 ml / min by the cockcroft gault formula * total serum bilirubin \< 2 x uln * alkaline phosphatase \< 2 x uln, ast (sgot) and alt (sgpt) \< 3 x uln;

inclusion criteria: adult (≥ 18 years old) men or women, hospitalized or not hospitalized, diagnosed for sars-cov-2 infection by pcr, with at least one associated risk factor. considered risk factors are: age ≥ 65 years obesity defined as bmi ≥ 30 recent history of uncontrolled high blood pressure (sbp > 150 mm hg dbp >100 mm hg) according to investigator treated diabetes (type i or ii) history of ischemic cardiovascular disease symptomatic patients at enrollment. symptoms are defined as fever (body temperature ≥ 37.8 c oral/tympanic, or ≥ 38.2 c rectal) for more than 24 hours associated either with headache, sore throat, dry cough, fatigue, chest pain or choking sensation (with no associated respiratory distress), myalgia, anosmia or ageusia. patients with pulse oximetry arterial saturation ≥ 92 % on room air at enrolment. patients with the following hematological and biochemical laboratory parameters obtained within 7 days prior to day 0: hemoglobin above 9.0 g / dl absolute neutrophil count ≥ 1000 / mm3 platelets ≥ 100 000 mm3; creatinine clearance ≥ 50 ml / min by the cockcroft gault formula total serum bilirubin < 2 x uln alkaline phosphatase < 2 x uln, ast (sgot) and alt (sgpt) < 3 x uln;

inclusion criteria: adult (≥ 18 years old) men or women, hospitalized or not hospitalized, diagnosed for sars-cov-2 infection by pcr, with at least one associated risk factor. considered risk factors are: age ≥ 65 years obesity defined as bmi ≥ 30 recent history of uncontrolled high blood pressure (sbp > 150 mm hg dbp >100 mm hg) according to investigator treated diabetes (type i or ii) history of ischemic cardiovascular disease symptomatic patients at enrollment. symptoms are defined as fever (body temperature ≥ 37.8 c oral/tympanic, or ≥ 38.2 c rectal) for more than 24 hours associated either with headache, sore throat, dry cough, fatigue, chest pain or choking sensation (with no associated respiratory distress), myalgia, anosmia or ageusia. patients with pulse oximetry arterial saturation ≥ 92 % on room air at enrolment. patients with the following hematological and biochemical laboratory parameters obtained within 7 days prior to day 0: hemoglobin above 9.0 g / dl absolute neutrophil count ≥ 1000 / mm3 platelets ≥ 100 000 mm3; creatinine clearance ≥ 50 ml / min by the cockcroft gault formula total serum bilirubin < 2 x uln alkaline phosphatase < 2 x uln, ast (sgot) and alt (sgpt) < 3 x uln;

inclusion criteria: 1. adult (≥ 18 years old) men or women, hospitalized or not hospitalized, diagnosed for sars-cov-2 infection by pcr, with at least one associated risk factor. considered risk factors are: - age ≥ 65 years - obesity defined as bmi ≥ 30 - recent history of uncontrolled high blood pressure (sbp > 150 mm hg dbp >100 mm hg) according to investigator - treated diabetes (type i or ii) - history of ischemic cardiovascular disease 2. symptomatic patients at enrollment. symptoms are defined as fever (body temperature ≥ 37.8 c oral/tympanic, or ≥ 38.2 c rectal) for more than 24 hours associated either with headache, sore throat, dry cough, fatigue, chest pain or choking sensation (with no associated respiratory distress), myalgia, anosmia or ageusia. 3. patients with pulse oximetry arterial saturation ≥ 92 % on room air at enrolment. 4. patients with the following hematological and biochemical laboratory parameters obtained within 7 days prior to day 0: - hemoglobin above 9.0 g / dl - absolute neutrophil count ≥ 1000 / mm3 - platelets ≥ 100 000 mm3; - creatinine clearance ≥ 50 ml / min by the cockcroft gault formula - total serum bilirubin < 2 x uln - alkaline phosphatase < 2 x uln, ast (sgot) and alt (sgpt) < 3 x uln;

inclusion criteria: 1. adult (≥ 18 years old) men or women, hospitalized or not hospitalized, diagnosed for sars-cov-2 infection by pcr, with at least one associated risk factor. considered risk factors are: - age ≥ 65 years - obesity defined as bmi ≥ 30 - recent history of uncontrolled high blood pressure (sbp > 150 mm hg dbp >100 mm hg) according to investigator - treated diabetes (type i or ii) - history of ischemic cardiovascular disease 2. symptomatic patients at enrollment. symptoms are defined as fever (body temperature ≥ 37.8 c oral/tympanic, or ≥ 38.2 c rectal) for more than 24 hours associated either with headache, sore throat, dry cough, fatigue, chest pain or choking sensation (with no associated respiratory distress), myalgia, anosmia or ageusia. 3. patients with pulse oximetry arterial saturation ≥ 92 % on room air at enrolment. 4. patients with the following hematological and biochemical laboratory parameters obtained within 7 days prior to day 0: - hemoglobin above 9.0 g / dl - absolute neutrophil count ≥ 1000 / mm3 - platelets ≥ 100 000 mm3; - creatinine clearance ≥ 50 ml / min by the cockcroft gault formula - total serum bilirubin < 2 x uln - alkaline phosphatase < 2 x uln, ast (sgot) and alt (sgpt) < 3 x uln;