inclusion criteria: 1. should be at least 18 years of age 2. male or nonpregnant female, 3. diagnosed with covid-19 by pcr confirmed sars-cov-2 viral infection. 4. able to sign the consent form and agree to clinical samples collection (or their legal surrogates if subjects are or become unable to make informed decisions). 5. moderate or severe covid-19, defined as oxygen saturation (sao2) of 94% or less while they were breathing ambient air or significant clinical symptoms with chest x ray changes that require hospital admission. 6. patients had to be enrolled within 10 days of disease onset

inclusion criteria: 1. should be at least 18 years of age 2. male or nonpregnant female, 3. diagnosed with covid-19 by pcr confirmed sars-cov-2 viral infection. 4. able to sign the consent form and agree to clinical samples collection (or their legal surrogates if subjects are or become unable to make informed decisions). 5. moderate or severe covid-19, defined as oxygen saturation (sao2) of 94% or less while they were breathing ambient air or significant clinical symptoms with chest x ray changes that require hospital admission. 6. patients had to be enrolled within 10 days of disease onset

inclusion criteria: should be at least 18 years of age male or nonpregnant female, diagnosed with covid-19 by pcr confirmed sars-cov-2 viral infection. able to sign the consent form and agree to clinical samples collection (or their legal surrogates if subjects are or become unable to make informed decisions). moderate or severe covid-19, defined as oxygen saturation (sao2) of 94% or less while they were breathing ambient air or significant clinical symptoms with chest x ray changes that require hospital admission. patients had to be enrolled within 10 days of disease onset

inclusion criteria: should be at least 18 years of age male or nonpregnant female, diagnosed with covid-19 by pcr confirmed sars-cov-2 viral infection. able to sign the consent form and agree to clinical samples collection (or their legal surrogates if subjects are or become unable to make informed decisions). moderate or severe covid-19, defined as oxygen saturation (sao2) of 94% or less while they were breathing ambient air or significant clinical symptoms with chest x ray changes that require hospital admission. patients had to be enrolled within 10 days of disease onset

inclusion criteria: 1. should be at least 18 years of age 2. male or nonpregnant female, 3. diagnosed with covid-19 by pcr confirmed sars-cov-2 viral infection. 4. able to sign the consent form and agree to clinical samples collection (or their legal surrogates if subjects are or become unable to make informed decisions). 5. moderate or severe covid-19, defined as oxygen saturation (sao2) of 94% or less while they were breathing ambient air or significant clinical symptoms with chest x ray changes that require hospital admission. 6. patients had to be enrolled within 10 days of disease onset

inclusion criteria: 1. should be at least 18 years of age 2. male or nonpregnant female, 3. diagnosed with covid-19 by pcr confirmed sars-cov-2 viral infection. 4. able to sign the consent form and agree to clinical samples collection (or their legal surrogates if subjects are or become unable to make informed decisions). 5. moderate or severe covid-19, defined as oxygen saturation (sao2) of 94% or less while they were breathing ambient air or significant clinical symptoms with chest x ray changes that require hospital admission. 6. patients had to be enrolled within 10 days of disease onset