1. Male and female, older than 18 years, 2. Patients with confirmed COVID19, 3. Need to continue the antivirus therapy, 4. Agree to sign the informed consent, 5. Able to ingest, absorb and tolerate oral medication, 6. Agree to collect clinical samples, 7. Consent to contraceptive measures for sex within 7 days of the last oral medication.

1. Male and female, older than 18 years, 2. Patients with confirmed COVID19, 3. Need to continue the antivirus therapy, 4. Agree to sign the informed consent, 5. Able to ingest, absorb and tolerate oral medication, 6. Agree to collect clinical samples, 7. Consent to contraceptive measures for sex within 7 days of the last oral medication.