1. The doctor believes that the patient is not suitable to participate in this trial, including those who may not cooperate, do not comply with the requirements of the procedure, or participate in this trial may put the patient in an unsafe situation. 2. Pregnant or lactation periods women, 3. Immunoglobulin allergy, 4. Immunoglobulin A deficiency, 5. The clinical symptoms are mild or reach the standard of severe or critical. Mild symptoms: Clinical symptoms are mild and no pneumonia on imaging. Severe patients meet any of the following: 1) respiratory distress, RR >=30 beats / min, 2) in resting state, oxygen saturation <=93%, 3) partial pressure of oxygen in arterial blood (PaO2) / oxygen concentration (FiO2) <=300mmHg (1mmHg=0.133kPa) Critically ill patients meet any of the following: 1) respiratory failure and need mechanical ventilation, 2) shock, 3) patients with other organ failure need ICU monitoring treatment. 6. There are diseases that may increase the risk of thrombosis, such as cold globulinemia, severe refractory hypertriglyceridemia, clinically defined monoclonal gamma globulinemia, etc. 7. High titer of anti-novel coronavirus antibody RBDIgG (higher than 1) could be detected. 8. Received any experimental treatment for novel coronavirus infection within 30 days before screening, 9. The researchers judged that the patients had the following life-threatening conditions, including, but not limited to, Phammer F < 100mmHg, near-death state or expected survival time less than 24 hours, severe septic shock or disseminated intravascular coagulation ((DIC)), etc., 10. Severe congestive heart failure, or other relative contraindications for plasma transfusion determined by researchers.

1. The doctor believes that the patient is not suitable to participate in this trial, including those who may not cooperate, do not comply with the requirements of the procedure, or participate in this trial may put the patient in an unsafe situation. 2. Pregnant or lactation periods women, 3. Immunoglobulin allergy, 4. Immunoglobulin A deficiency, 5. The clinical symptoms are mild or reach the standard of severe or critical. Mild symptoms: Clinical symptoms are mild and no pneumonia on imaging. Severe patients meet any of the following: 1) respiratory distress, RR >=30 beats / min, 2) in resting state, oxygen saturation <=93%, 3) partial pressure of oxygen in arterial blood (PaO2) / oxygen concentration (FiO2) <=300mmHg (1mmHg=0.133kPa) Critically ill patients meet any of the following: 1) respiratory failure and need mechanical ventilation, 2) shock, 3) patients with other organ failure need ICU monitoring treatment. 6. There are diseases that may increase the risk of thrombosis, such as cold globulinemia, severe refractory hypertriglyceridemia, clinically defined monoclonal gamma globulinemia, etc. 7. High titer of anti-novel coronavirus antibody RBDIgG (higher than 1) could be detected. 8. Received any experimental treatment for novel coronavirus infection within 30 days before screening, 9. The researchers judged that the patients had the following life-threatening conditions, including, but not limited to, Phammer F < 100mmHg, near-death state or expected survival time less than 24 hours, severe septic shock or disseminated intravascular coagulation ((DIC)), etc., 10. Severe congestive heart failure, or other relative contraindications for plasma transfusion determined by researchers.