(1) aged 18-80 years old, (2) severe (including critical risk factors) and critical patients with confirmed novel coronavirus pneumonia, (3) blood CRP and ESR were more than twice higher than normal or TNFa and Il-6 were higher than normal, (4) sign the informed consent.

(1) aged 18-80 years old, (2) severe (including critical risk factors) and critical patients with confirmed novel coronavirus pneumonia, (3) blood CRP and ESR were more than twice higher than normal or TNFa and Il-6 were higher than normal, (4) sign the informed consent.