inclusion criteria: * presumptive positive laboratory test for covid-19 based on local laboratory standard * age greater than or equal to 18 years of age * admission to the hospital with a respiratory sofa \>=1 and increased oxygen requirement compared to baseline among those on home o2 * randomization within 48 hours of presentation of hospital admission or within 48 hours of a positive test result, whichever is later

inclusion criteria: * presumptive positive laboratory test for covid-19 based on local laboratory standard * age greater than or equal to 18 years of age * admission to the hospital with a respiratory sofa \>=1 and increased oxygen requirement compared to baseline among those on home o2 * randomization within 48 hours of presentation of hospital admission or within 48 hours of a positive test result, whichever is later

inclusion criteria: - presumptive positive laboratory test for covid-19 based on local laboratory standard - age greater than or equal to 18 years of age - admission to the hospital with a respiratory sofa >=1 and increased oxygen requirement compared to baseline among those on home o2 - randomization within 48 hours of presentation of hospital admission or within 48 hours of a positive test result, whichever is later

inclusion criteria: - presumptive positive laboratory test for covid-19 based on local laboratory standard - age greater than or equal to 18 years of age - admission to the hospital with a respiratory sofa >=1 and increased oxygen requirement compared to baseline among those on home o2 - randomization within 48 hours of presentation of hospital admission or within 48 hours of a positive test result, whichever is later