(1) Combined with high blood pressure, diabetes, coronary heart disease and other underlying disease, (2) Combined with malignant tumor or a medical history of malignant tumor, (3) Pregnant or lactating women, (4) Suffering from severe mental illness, (5) Medical history of unstable angor pectoris or myocardial?infarction within 6 months, coronary arteriography, it indicates severe stenosis of the main branch of the coronary artery, (6) Medical history of cerebral infarction or cerebral hemorrhage within 6 months, (7) Intolerant or allergic to interferon preparations, (8) The investigator determined that the patients were not eligible for the trial.

(1) Combined with high blood pressure, diabetes, coronary heart disease and other underlying disease, (2) Combined with malignant tumor or a medical history of malignant tumor, (3) Pregnant or lactating women, (4) Suffering from severe mental illness, (5) Medical history of unstable angor pectoris or myocardial?infarction within 6 months, coronary arteriography, it indicates severe stenosis of the main branch of the coronary artery, (6) Medical history of cerebral infarction or cerebral hemorrhage within 6 months, (7) Intolerant or allergic to interferon preparations, (8) The investigator determined that the patients were not eligible for the trial.