(1) The novel coronavirus was detected at the age of 18~70 years when signing the informed consent, (2) the nucleic acid test of the pharyngeal test, sputum, lower respiratory tract secretions, blood and so on (RT-PCR detection of the new coronavirus nucleic acid positive) and the sequencing of the virus gene, which were highly homologous with the known new coronavirus, and confirmed that the 2019-nCoV was detected. Chest X ray and CT imaging confirmed pneumonia (manifested as pulmonary infiltration, single lung or multiple lung lesions, mainly located in the lung field and subpleural area of the Chinese and foreign countries. Lesions were presented as mosaic sign caused by small patch glass, consolidation and coexistence of small nodules, ground glass shadow and air retention). Lung imaging showed significant progress in 24-48 hours. The patients had no improvement or progressive aggravation after standard anti bacteria treatment, ? had fever, fatigue, cough, shortness of breath and other symptoms, because of fever (body temperature = 37.3 ?), respiratory rate > 30 times / min, SpO2 = 93% (quiet, resting state), oxygenation index = 300, ? The total number of leukocytes in the early stage of onset was normal / decreased, or lymphocyte count decreased. C reactive protein and ESR increased, PCT was normal. (6) epidemiological history (two weeks before onset, Hubei or other higher incidence rate of travel history, or contact with persons from above regions, or the removal of other suspected and confirmed cases), the time from onset to less than 14 days. The subjects are willing to be randomly assigned to any designated treatment group, ? on the basis of current routine treatment, the patients are still in progress, fully informed and signed with the patients and their families, ? they must agree not to participate in another study of the drug under study before the 28th day after the completion of the study.

(1) The novel coronavirus was detected at the age of 18~70 years when signing the informed consent, (2) the nucleic acid test of the pharyngeal test, sputum, lower respiratory tract secretions, blood and so on (RT-PCR detection of the new coronavirus nucleic acid positive) and the sequencing of the virus gene, which were highly homologous with the known new coronavirus, and confirmed that the 2019-nCoV was detected. Chest X ray and CT imaging confirmed pneumonia (manifested as pulmonary infiltration, single lung or multiple lung lesions, mainly located in the lung field and subpleural area of the Chinese and foreign countries. Lesions were presented as mosaic sign caused by small patch glass, consolidation and coexistence of small nodules, ground glass shadow and air retention). Lung imaging showed significant progress in 24-48 hours. The patients had no improvement or progressive aggravation after standard anti bacteria treatment, ? had fever, fatigue, cough, shortness of breath and other symptoms, because of fever (body temperature = 37.3 ?), respiratory rate > 30 times / min, SpO2 = 93% (quiet, resting state), oxygenation index = 300, ? The total number of leukocytes in the early stage of onset was normal / decreased, or lymphocyte count decreased. C reactive protein and ESR increased, PCT was normal. (6) epidemiological history (two weeks before onset, Hubei or other higher incidence rate of travel history, or contact with persons from above regions, or the removal of other suspected and confirmed cases), the time from onset to less than 14 days. The subjects are willing to be randomly assigned to any designated treatment group, ? on the basis of current routine treatment, the patients are still in progress, fully informed and signed with the patients and their families, ? they must agree not to participate in another study of the drug under study before the 28th day after the completion of the study.