(1) Age < 18 or > 65, (2) Patients with severe heart, brain, lung, kidney dysfunction, endocrine disease, hematopoiesis system disease or other serious diseases and psychosis, (3) Pregnant and lactating women.

(1) Age < 18 or > 65, (2) Patients with severe heart, brain, lung, kidney dysfunction, endocrine disease, hematopoiesis system disease or other serious diseases and psychosis, (3) Pregnant and lactating women.