1. The pneumonia patients with severe new coronavirus infection met one of the following conditions: respiratory distress, RR <=30 times / min, or SaO2 / SpO2 <=93% in resting state, or arterial partial pressure of oxygen (PaO2) / concentration of oxygen (FiO2) <=300MMHG (1mmhg = 0.133kpa), 2. Pneumonia patients with severe new coronavirus infection meet one of the following conditions: respiratory failure and need mechanical ventilation, or shock, or other organ failure combined with ICU monitoring treatment, 3.Severe liver disease (such as child Pugh score >=C, AST > 5 times upper limit), 4. Patients with contraindications specified in the instructions of danorevir and ritonavir tablets, 5. Patients who have taken or are taking protease inhibitor drugs, 6. The pregnancy test of female subjects in the screening period was positive, 7. The researchers judged that it was not suitable to participate in this clinical trial (for example, patients who may be transferred to another hospital during the study period, patients with multiple basic diseases, etc.).

1. The pneumonia patients with severe new coronavirus infection met one of the following conditions: respiratory distress, RR <=30 times / min, or SaO2 / SpO2 <=93% in resting state, or arterial partial pressure of oxygen (PaO2) / concentration of oxygen (FiO2) <=300MMHG (1mmhg = 0.133kpa), 2. Pneumonia patients with severe new coronavirus infection meet one of the following conditions: respiratory failure and need mechanical ventilation, or shock, or other organ failure combined with ICU monitoring treatment, 3.Severe liver disease (such as child Pugh score >=C, AST > 5 times upper limit), 4. Patients with contraindications specified in the instructions of danorevir and ritonavir tablets, 5. Patients who have taken or are taking protease inhibitor drugs, 6. The pregnancy test of female subjects in the screening period was positive, 7. The researchers judged that it was not suitable to participate in this clinical trial (for example, patients who may be transferred to another hospital during the study period, patients with multiple basic diseases, etc.).