1. Patients who are participating in clinical trials of other drugs, 2. Pregnant or lactating women, 3. ALT / AST > 2-fold ULN, 4. Expected survival time < 1 week, 5. With serious liver disease, 6. Patients taking orally anti-tumor drugs or immunomodulatory drugs for a long time, 7. Patients who are participating in other clinical trials, 8. The researchers think that other reasons are not suitable for clinical trials.

1. Patients who are participating in clinical trials of other drugs, 2. Pregnant or lactating women, 3. ALT / AST > 2-fold ULN, 4. Expected survival time < 1 week, 5. With serious liver disease, 6. Patients taking orally anti-tumor drugs or immunomodulatory drugs for a long time, 7. Patients who are participating in other clinical trials, 8. The researchers think that other reasons are not suitable for clinical trials.